Journal
BIOACTIVE MATERIALS
Volume 8, Issue -, Pages 381-395Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.05.053
Keywords
Titanium-copper alloy implants; Anti-infection; Oral microbiology; Biosafety
Funding
- Bureau of International Cooperation, Chinese Academy of Sciences [174321KYSB20180006]
- National Key Research and Development Program of China [2018YFC1106600, 2016YFC1100600]
- Natural Science Foundation of China [51631009, 31870954]
- Liaoning Revitalization Talents Program [XLYC1807069]
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This study focused on investigating the anti-infection ability and underlying mechanism of a novel titanium-copper dental implant. The titanium-copper implant demonstrated remarkable anti-infection potentials and excellent biocompatibility compared to the pure titanium implant. The underlying anti-infection mechanism was found to involve maintaining the oral microbiota balance, preventing the formation of an acidic microenvironment, and inhibiting the accumulation of acidogens and pathogens.
This work was focused on study of anti-infection ability and its underlying mechanism of a novel dental implant made of titanium-copper (TiCu) alloy. In general, most studies on antibacterial implants have used a single pathogen to test their anti-infection ability using infectious animal models. However, dental implant-associated infections are polymicrobial diseases. We innovatively combine the classic ligature model in dogs with sucrose-rich diets to induce oral infections via the canine native oral bacteria. The anti-infection ability, biocompatibility and underlying mechanism of TiCu implant were systematically investigated in comparison with pure Ti implant via general inspection, hematology, imageology (micro-CT), microbiology (16S rDNA and metagenome), histology, and Cu ion detections. Compared with Ti implant, TiCu implant demonstrated remarkable anti-infection potentials with excellent biocompatibility. Additionally, the underlying anti-infection mechanism of TiCu implant was considered to involve maintaining the oral microbiota homeostasis. It was found that the carbohydrates in the plaques formed on the surface of TiCu implant were metabolized through the tricarboxylic acid cycle (TCA) cycles, which prevented the formation of an acidic microenvironment and inhibited the accumulation of acidogens and pathogens, thereby maintaining the microflora balance between aerobic and anaerobic bacteria.
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