Journal
BIOACTIVE MATERIALS
Volume 7, Issue -, Pages 98-111Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.05.039
Keywords
Hydrogel; Injectability; Self-healing; Conductivity; Traumatic spinal cord injury
Funding
- National Natural Science Foundation of China [51932002, 51903087, 31771080]
- Science and Technology Innovation Team Project of Foshan [2018IT100101]
- Sino-Singapore International Joint Research Institute [203-A018004]
- Joint Fund of Ministry of Education for Equipment Preresearch [6141A02022632]
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This study developed an injectable self-healing electroconductive hydrogel for the treatment of traumatic spinal cord injury. The hydrogel showed mechanical and conductive properties similar to natural spinal cord tissues, promoting tissue repair and achieving significant locomotor function restoration in a rat model.
Injectable biomaterial-based treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury (SCI) by bridging cavity spaces. However, there are limited reports of injectable, electroconductive hydrogels with self-healing properties being employed for the treatment of traumatic SCI. Hence, a natural extracellular matrix (ECM) biopolymer (chondroitin sulphate and gelatin)-based hydrogel containing polypyrrole, which imparted electroconductive properties, is developed for traumatic SCI repair. The resulting hydrogels showed mechanical (similar to 928 Pa) and conductive properties (4.49 mS/cm) similar to natural spinal cord tissues. Moreover, the hydrogels exhibited shear-thinning and self-healing abilities, which allows it to be effectively injected into the injury site and to fill the lesion cavity to accelerate the tissue repair of traumatic SCI. In vitro, electroconductive ECM hydrogels promoted neuronal differentiation, enhanced axon outgrowth, and inhibited astrocyte differentiation. The electroconductive ECM hydrogel activated endogenous neural stem cell neurogenesis in vivo (n = 6), and induced myelinated axon regeneration into the lesion site via activation of the PI3K/AKT and MEK/ERK pathways, thereby achieving significant locomotor function restoration in rats with spinal cord injury (p < 0.001, compared to SCI group). Overall, the injectable self-healing electroconductive ECM-based hydrogels developed in this study are ideal biomaterials for treatment of traumatic SCI.
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