Journal
BIOACTIVE MATERIALS
Volume 7, Issue -, Pages 466-477Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.05.034
Keywords
sdTEVGs; On-demand programmed responsive systems; Neural exosomes; Nerve reconstruction; Intimal hyperplasia
Funding
- National Key Research and Development Plan Young Scientists Program [2017YFA0106000]
- National Science Fund for Outstanding Young Scholars [31822021]
- National Science Foundation of China [31771057]
- National Key Research and Development Plan [2016YFC1101100]
Ask authors/readers for more resources
Inspired by the bionic regulation of nerves on blood vessels, researchers discovered that released neural exosomes can inhibit the abnormal transformation of vascular smooth muscle cells, addressing the issue of intimal hyperplasia in small-diameter tissue-engineered vascular grafts under hyperglycemia.
Small-diameter tissue-engineered vascular grafts (sdTEVGs) with hyperglycemia resistance have not been constructed. The intimal hyperplasia caused by hyperglycemia remains problem to hinder the patency of sdTEVGs. Here, inspired by bionic regulation of nerve on vascular, we found the released neural exosomes could inhibit the abnormal phenotype transformation of vascular smooth muscle cells (VSMCs). The transformation was a prime culprit causing the intimal hyperplasia of sdTEVGs. To address this concern, sdTEVGs were modified with an on-demand programmable dual-responsive system of ultrathin hydrogels. An external primary Reactive Oxygen Species (ROS)-responsive Netrin-1 system was initially triggered by local inflammation to induce nerve remolding of the sdTEVGs overcoming the difficulty of nerve regeneration under hyperglycemia. Then, the internal secondary ATP-responsive DENND1A (guanine nucleotide exchange factor) system was turned on by the neurotransmitter ATP from the immigrated nerve fibers to stimulate effective release of neural exosomes. The results showed nerve fibers grow into the sdTEVGs in diabetic rats 30 days after transplantation. At day 90, the abnormal VSMCs phenotype was not detected in the sdTEVGs, which maintained long-time patency without intima hyperplasia. Our study provides new insights to construct vascular grafts resisting hyperglycemia damage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available