Journal
BIOACTIVE MATERIALS
Volume 6, Issue 11, Pages 3904-3923Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.03.040
Keywords
Hydrogel; Microfabrication; Bioprinting; Textiles; Tissue engineering; Regenerative medicine
Funding
- Ministry of Higher Education, Research and Innovation, France
- National Institutes of Health, United States [GM126831, AR073822]
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Natural hydrogels are highlighted as promising biomaterials in tissue engineering applications due to their biocompatibility and biodegradability. Innovative biofabrication techniques, such as textile techniques and 3D bioprinting, play a significant role in developing advanced scaffolds for tissue engineering. This review also discusses the emerging applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering.
Natural hydrogels are one of the most promising biomaterials for tissue engineering applications, due to their biocompatibility, biodegradability, and extracellular matrix mimicking ability. To surpass the limitations of conventional fabrication techniques and to recapitulate the complex architecture of native tissue structure, natural hydrogels are being constructed using novel biofabrication strategies, such as textile techniques and three-dimensional bioprinting. These innovative techniques play an enormous role in the development of advanced scaffolds for various tissue engineering applications. The progress, advantages, and shortcomings of the emerging biofabrication techniques are highlighted in this review. Additionally, the novel applications of biofabricated natural hydrogels in cardiac, neural, and bone tissue engineering are discussed as well.
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