Journal
BIOACTIVE MATERIALS
Volume 6, Issue 12, Pages 4568-4579Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.04.041
Keywords
Peri-implantitis; Dimethylaminododecyl methacrylate; Animal model; Osseointegration; Bioactive and therapeutic
Funding
- National Key Research and Development Program of China [2016YFC1102700, 2016YFC1102701]
- National Natural Science Foundation of China [81870759, 82071106]
- Innovative Research Team Program of Sichuan Province
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Peri-implantitis is a major problem causing implant failure, with early anti-infection and osseointegration promotion being key factors to address this issue. A novel compound PD, combined with MAO treatment, shows potential in inhibiting severe peri-implantitis by exhibiting anti-infection and osteogenic properties.
Peri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials. The method shows good osteogenic properties but weak antibacterial effect. Therefore, we developed combined strategies to combat severe peri-implantitis, which included the use of a novel compound, PD, comprising dendrimers poly (amidoamine) (PAMAM) loading dimethylaminododecyl methacrylate (DMADDM) as well as MAO treatment. Here, we explored the chemical properties of the novel compound PD, and proved that this compound was successfully synthesized, with the loading efficiency and encapsulation efficiency of 23.91% and 31.42%, respectively. We further report the two-stage double benefits capability of PD + MAO: (1) in the first stage, PD + MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo; (2) in the second stage, PD + MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo. This study first reports the two-staged, double benefits of PD + MAO, and demonstrates its potential in clinical applications for inhibiting peri-implantitis, especially in patients with severe infection risk.
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