Journal
FRONTIERS IN PHYSICS
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphy.2022.791145
Keywords
microbubbles; contrast enhanced ultrasound; imaging; nonlinear scattering; subharmonic; ultrasound localization microscopy; super resolution; harmonic
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Funding
- NSERC [RGPIN-201906969]
- Fonds de recherche du Quebec-Nature et Technologies [2021-NC-282699]
- Heart and Stroke Foundation of Canada [G-18-0022133]
- Canada Research Chair program
- Burroughs Wellcome Fund [1018212.03]
- Career at the Scientific Interface award from the Burroughs Wellcome Fund (BWF-CASI)
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This review article provides an overview of the development and applications of microbubble contrast agents in medical ultrasound imaging, including their basic physics, imaging techniques, and new emerging applications.
The development of microbubble contrast agents has broadened the scope of medical ultrasound imaging. Along with dedicated imaging techniques, these agents provide enhanced echoes from the blood pool and have enabled diagnostic ultrasound to assess and quantify microvascular blood flow. Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, and it continues to evolve and develop through innovative technological advancements. In this review article, we present an overview of the basic microbubble physics and bubble-specific imaging techniques that enable this modality, and follow this with a discussion on new and emerging applications.
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