4.7 Article

Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway

Related references

Note: Only part of the references are listed.
Review Veterinary Sciences

From Conventional to Precision Therapy in Canine Mammary Cancer: A Comprehensive Review

Guillermo Valdivia et al.

Summary: Canine mammary tumors are common in intact female dogs, with mammary cancer representing a significant portion. Studies on new treatments for canine mammary cancer are promising and can provide insights into human breast cancer research. The lack of translation from in vitro studies to clinical trials in dogs with CMC is highlighted as a gap in current research.

FRONTIERS IN VETERINARY SCIENCE (2021)

Article Oncology

Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells

Federica Mannino et al.

Summary: The natural CB2R agonist beta-caryophyllene (BCP) exhibits significant anti-cancer and anti-proliferative effects in multiple myeloma (MM) cells by activating apoptosis and modulating different molecular pathways. This suggests that BCP could be a potential therapeutic approach for improving anti-myeloma therapy.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Tripterine and miR-184 show synergy to suppress breast cancer progression

Jinjun Wang

Summary: The study shows that tripterine inhibits the viability, proliferation, migration, and invasion capacity of breast cancer cells, while also reducing Bcl-2 protein expression and increasing Bax protein expression. High expression of miR-184 in tripterine-treated breast cancer cells leads to decreased viability, proliferation, and invasion abilities. Interference with miR-184 counteracts the effects of tripterine on breast cancer cells.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Oncology

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

Xihong Liu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Immunology

Caspases in Cell Death, Inflammation, and Disease

Nina Van Opdenbosch et al.

IMMUNITY (2019)

Article Oncology

Cancer Statistics in China, 2015

Wanqing Chen et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

Article Integrative & Complementary Medicine

Celastrol targets IRAKs to block Toll-like receptor 4-mediated nuclear factor-κB activation

Yu-fan Shen et al.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2016)

Article Chemistry, Medicinal

Design and synthesis of celastrol derivatives as anticancer agents

Wen-Jian Tang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Biology

Comparative oncology: what dogs and other species can teach us about humans with cancer

Joshua D. Schiffman et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Article Cell Biology

HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS

C. Zhang et al.

CELL DEATH & DISEASE (2015)

Article Veterinary Sciences

Canine mammary carcinoma cell line are resistant to chemosensitizers: verapamil and cyclosporin A

M. Krol et al.

POLISH JOURNAL OF VETERINARY SCIENCES (2014)

Article Veterinary Sciences

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells

Karol M. Pawlowski et al.

BMC VETERINARY RESEARCH (2013)

Article Pharmacology & Pharmacy

Tripterygium wilfordii bioactive compounds as anticancer and anti-inflammatory agents

Kwong-Fai Wong et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2012)

Article Plant Sciences

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

Ming-Fang He et al.

JOURNAL OF ETHNOPHARMACOLOGY (2009)