Journal
FRONTIERS IN PUBLIC HEALTH
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpubh.2021.728969
Keywords
SARS-CoV-2 (2019-nCoV); nasopharyngeal swabs; nasal swab; rapid antigen detection test; RT-PCR; viral diagnostic; COVID-19
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In addition to mass vaccination, early detection and isolation of infected cases is the best way to mitigate an outbreak. This study demonstrates the potential use of rapid antigen detection test (RADT) as a cost-effective and rapid method for detecting COVID-19.
IntroductionThe best way to mitigate an outbreak besides mass vaccination is via early detection and isolation of infected cases. As such, a rapid, cost-effective test for the early detection of COVID-19 is required. MethodsThe study included 4,183 mildly symptomatic patients. A nasal and nasopharyngeal sample obtained from each patient was analyzed to determine the diagnostic ability of the rapid antigen detection test (RADT, nasal swab) in comparison with the current gold-standard (RT-PCR, nasopharyngeal swab). ResultsThe calculated sensitivity and specificity of the RADT was 82.1 and 99.1%, respectively. Kappa's coefficient of agreement between the RADT and RT-PCR was 0.859 (p < 0.001). Stratified analysis showed that the sensitivity of the RADT improved significantly when lowering the cut-off RT-PCR Ct value to 24. ConclusionOur study's results support the potential use of nasal swab RADT as a screening tool in mildly symptomatic patients, especially in patients with higher viral loads.
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