4.6 Review

The Value of a Complete Blood Count (CBC) for Sepsis Diagnosis and Prognosis

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Prognostic value of the combined variability of mean platelet volume and neutrophil percentage for short-term clinical outcomes of sepsis patients

Lan Gao et al.

Summary: The study showed that an MPV-CV >= 15.00% + NEU%-CV >= 16.00% is an independent predictive factor for in-hospital mortality in patients with sepsis.

POSTGRADUATE MEDICINE (2021)

Article Medical Laboratory Technology

Monocyte distribution width as a biomarker of sepsis in the intensive care unit: A pilot study

Luisa Agnello et al.

Summary: This study assessed the role of monocyte distribution width as a diagnostic biomarker of sepsis in the intensive care unit. The results showed that monocyte distribution width was significantly higher in sepsis patients compared to non-sepsis patients, and it increased significantly when sepsis developed.

ANNALS OF CLINICAL BIOCHEMISTRY (2021)

Article Medical Laboratory Technology

Monocyte distribution width (MDW) parameter as a sepsis indicator in intensive care units

Elisa Piva et al.

Summary: The study evaluated the diagnostic accuracy and prognostication of monocyte distribution width (MDW) in sepsis for patients admitted to ICU. MDW values were significantly higher in patients with sepsis or septic shock compared to those without sepsis. The increase in MDW was not affected by the etiology of sepsis, including in patients with COVID-19, and it was found to decrease in sepsis survivors.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

Letter Hematology

Validation of monocyte distribution width decisional cutoff for sepsis detection in the acute setting

Luisa Agnello et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2021)

Article Anesthesiology

Fluctuation in red cell distribution width predicts disseminated intravascular coagulation morbidity and mortality in sepsis: a retrospective single-center study

Yi W. Fan et al.

Summary: The study found that RDW-SD and the increase rate of RDW are independent risk factors for the prognosis and DIC morbidity in patients with sepsis, and the occurrence of DIC and mortality rate continue to increase with an increase rate of RDW of at least 6%.

MINERVA ANESTESIOLOGICA (2021)

Article Immunology

Participation of Monocyte Subpopulations in Progression of Experimental Endotoxemia (EE) and Systemic Inflammation

Yaroslav V. Radzyukevich et al.

Summary: Monocytes play a crucial role in the progression of systemic inflammation and sepsis by regulating immune response through phagocytosis, cytokine and chemokine synthesis, antigen presentation, and lymphocyte activation. Different monocyte subpopulations are important in determining the severity of systemic inflammation and could be potential targets for therapeutic intervention. However, the complexity of pathophysiology of systemic inflammation is influenced by individual differences of patients and variability in inflammation progression specifications.

JOURNAL OF IMMUNOLOGY RESEARCH (2021)

Review Neurosciences

COVID-19 and Alzheimer's Disease

Marcello Ciaccio et al.

Summary: SARS-CoV-2 can cause neurological symptoms, potentially affecting the nervous system and increasing the risk of developing neurodegenerative diseases, with a mutualistic relationship found with Alzheimer's Disease.

BRAIN SCIENCES (2021)

Article Medical Laboratory Technology

A new tool for sepsis screening in the Emergency Department

Luisa Agnello et al.

Summary: The study developed and evaluated the diagnostic accuracy of the Sepsis Index for early sepsis screening in the Emergency Department. Results showed that the Sepsis Index had higher specificity and predictive value for sepsis compared to using only MDW, without sacrificing sensitivity.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

Article Medicine, Research & Experimental

Association Between Red Cell Distribution Width and Hospital Mortality in Patients with Sepsis

Yide Li et al.

Summary: The study suggests that red blood cell distribution width (RDW) may have predictive value in predicting hospital mortality in patients with sepsis, independent of other severity scores like SOFA and APACHE IV.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

Article Multidisciplinary Sciences

Monocyte distribution width compared with C-reactive protein and procalcitonin for early sepsis detection in the emergency department

A. la Woo et al.

Summary: Monocyte distribution width (MDW) has been evaluated as a potential early biomarker for sepsis, showing diagnostic performance comparable to conventional markers like C-reactive protein (CRP) and procalcitonin (PCT). Combining MDW with quick Sequential Organ Failure Assessment (qSOFA) improves diagnostic performance for early sepsis, with MDW demonstrating the highest value in sepsis patients.

PLOS ONE (2021)

Review Medicine, General & Internal

Sepsis-Pathophysiology and Therapeutic Concepts

Dominik Jarczak et al.

Summary: Sepsis is a life-threatening global disease burden, with current treatment mainly relying on basic measures and limited effectiveness of adjuvant therapy. Therefore, a deeper understanding of sepsis immunopathophysiology is needed to explore more promising therapeutic approaches.

FRONTIERS IN MEDICINE (2021)

Review Hematology

Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment

Michela Giustozzi et al.

Summary: Sepsis is a complex syndrome with a high incidence, with coagulopathy being a leading factor associated with mortality. Thrombocytopenia is a known predictor of worse prognosis during sepsis.

BLOOD REVIEWS (2021)

Review Infectious Diseases

Silent existence of eosinopenia in sepsis: a systematic review and meta-analysis

Yao Lin et al.

Summary: Eosinopenia has a high incidence in sepsis, but it does not have superiority compared with conventional biomarkers for the diagnosis of sepsis. However, eosinopenia can still be used as a simple, convenient, fast, and inexpensive biomarker for clinical diagnosis of sepsis. Further large clinical trials are still needed to re-evaluate eosinopenia as a biomarker for sepsis.

BMC INFECTIOUS DISEASES (2021)

Article Multidisciplinary Sciences

Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction

Samuel H. Belok et al.

Summary: The study confirmed that leukopenia is associated with a higher risk of death in ICU patients, although it is correlated with thrombocytopenia. In a small subset of patients, leukopenia may present as a sign of sepsis before thrombocytopenia occurs.

PLOS ONE (2021)

Article Medicine, General & Internal

Independent Validation of Sepsis Index for Sepsis Screening in the Emergency Department

Luisa Agnello et al.

Summary: This study validated the performance of SI as a tool for early detection of patients at high risk of sepsis, showing that SI has increased specificity, positive predictive value, and positive likelihood ratio compared to MDW alone in terms of diagnostic accuracy for sepsis screening.

DIAGNOSTICS (2021)

Review Primary Health Care

Role of immature platelet fraction (IPF) in sepsis patients: A systematic review

Abubakar Tauseef et al.

Summary: Studies have shown that immature platelet fraction can predict the onset of sepsis, and higher IPF values are associated with increased mortality.

JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE (2021)

Article Critical Care Medicine

Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter international European prospective study

Pierre Hausfater et al.

Summary: MDW in combination with WBC has good diagnostic accuracy for sepsis detection, especially in patients with lower pretest sepsis probability. We suggest the use of MDW as a systematic screening test, used together with qSOFA score to improve the accuracy of sepsis diagnosis in the emergency department.

CRITICAL CARE (2021)

Review Medicine, General & Internal

Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis

Dimitrios Velissaris et al.

Summary: Sepsis is a severe condition with high mortality rate and an ideal biomarker remains unknown. Presepsin may be a valuable tool for assessing septic patients and plays an important role in the emergency department and intensive care unit. Further research is needed to evaluate the clinical implications of utilizing presepsin measurements in the workup of sepsis.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

Review Medicine, General & Internal

The Advancement in Detecting Sepsis and Its Outcome: Usefulness of Procalcitonin in Diagnosing Sepsis and Predicting Fatal Outcomes in Patients Admitted to Intensive Care Unit

Mushrin Malik et al.

Summary: This systematic review evaluates the use of procalcitonin (PCT) for diagnosing and predicting severe outcomes in patients admitted to ICU, showing promising results with PCT having good predictive value in detecting and managing sepsis, severe sepsis, and mortality for a more favorable clinical outcome.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

Article Medicine, General & Internal

Red Cell Distribution Width As a Predictor of Mortality in Patients With Sepsis

Vinai Krishna et al.

Summary: This study found that an increase in red cell distribution width (RDW) from baseline during the initial 72 hours after admission is significantly associated with adverse clinical outcomes including mortality in patients with severe sepsis and septic shock. The mortality in the rise in the RDW group, as well as overall mortality, were significantly higher than the mortality in the reduced RDW group. Serial RDW measurements could be used as a prognostic factor in severe sepsis and septic shock.

CUREUS JOURNAL OF MEDICAL SCIENCE (2021)

Article Medical Laboratory Technology

A new tool for sepsis screening in the Emergency Department

Luisa Agnello et al.

Summary: The study developed and evaluated the diagnostic accuracy of the Sepsis Index, which combines MDW and MMV, for screening sepsis in the Emergency Department. Sepsis Index showed improved specificity and diagnostic accuracy compared to MDW alone.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

Article Emergency Medicine

Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis

Zhiwei Huang et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

Review Medical Laboratory Technology

Diagnostic and prognostic value of red blood cell distribution width in sepsis: A narrative review

Zhi-De Hu et al.

CLINICAL BIOCHEMISTRY (2020)

Review Respiratory System

The complete blood count to diagnose septic shock

Joshua David Farkas

JOURNAL OF THORACIC DISEASE (2020)

Review Immunology

Pattern of human monocyte subpopulations in health and disease

Agnieszka Ozanska et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2020)

Article Medical Laboratory Technology

Presepsin and Midregional Proadrenomedullin in Pediatric Oncologic Patients with Febrile Neutropenia

Luisa Agnello et al.

LABORATORY MEDICINE (2020)

Article Medical Laboratory Technology

Monocyte distribution width (MDW) as a screening tool for sepsis in the Emergency Department

Luisa Agnello et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

Article Critical Care Medicine

Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA

Elliott D. Crouser et al.

JOURNAL OF INTENSIVE CARE (2020)

Article Cell Biology

Differences in monocyte subsets are associated with short-term survival in patients with septic shock

Marcela Hortova-Kohoutkova et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Oncology

Reviewing the value of leukocytes cell population data (CPD) in the management of sepsis

Eloisa Urrechaga

ANNALS OF TRANSLATIONAL MEDICINE (2020)

Article Critical Care Medicine

Role of the adaptive immune response in sepsis

Jack Brady et al.

INTENSIVE CARE MEDICINE EXPERIMENTAL (2020)

Article Medicine, General & Internal

Neutrophils to Lymphocyte Ratio: Earliest and Efficacious Markers of Sepsis

Fazal U. Rehman et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

Review Allergy

Mechanisms of eosinophilic inflammation

Makoto Nagata et al.

ASIA PACIFIC ALLERGY (2020)

Review Biology

Neutrophil activity in sepsis: a systematic review

C. B. Resende et al.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2020)

Article Medical Laboratory Technology

Mid-regional pro-adrenomedullin predicts poor outcome in non-selected patients admitted to an intensive care unit

Chiara Bellia et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2019)

Article Hematology

Immature granulocytes index as early marker of sepsis

Laura S. Ayres et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2019)

Review Emergency Medicine

Sepsis: mechanisms of bacterial injury to the patient

Hayk Minasyan

SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE (2019)

Article Obstetrics & Gynecology

The value of delta neutrophil index in neonatal sepsis diagnosis, follow-up and mortality prediction

Istemi Han Celik et al.

EARLY HUMAN DEVELOPMENT (2019)

Article Infectious Diseases

White blood cell count and eosinopenia as valuable tools for the diagnosis of bacterial infections in the ED

Charles-Eric Lavoignet et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2019)

Article Medicine, General & Internal

Prognostic Relevance of Altered Lymphocyte Subpopulations in Critical Illness and Sepsis

Philipp Hohlstein et al.

JOURNAL OF CLINICAL MEDICINE (2019)

Review Biochemistry & Molecular Biology

Platelets Are Critical Key Players in Sepsis

Fanny Vardon-Bounes et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Immunology

Platelets in Sepsis: An Update on Experimental Models and Clinical Data

Alice Assinger et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Cell Biology

Sepsis: Inflammation Is a Necessary Evil

Christina Nedeva et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Editorial Material Medical Laboratory Technology

Sepsis biomarkers: past, present and future

Giuseppe Lippi

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2019)

Review Critical Care Medicine

RBC Transfusion Strategies in the ICU: A Concise Review

Casey A. Cable et al.

CRITICAL CARE MEDICINE (2019)

Article Multidisciplinary Sciences

Kinetics of mean platelet volume predicts mortality in patients with septic shock

Fanny Vardon-Bounes et al.

PLOS ONE (2019)

Article Medical Laboratory Technology

Improvement in detecting sepsis using leukocyte cell population data (CPD)

Eloisa Urrechaga et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2019)

Article Immunology

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice

Adrian M. Piliponsky et al.

NATURE IMMUNOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Red blood cell distribution width: A marker of anisocytosis potentially associated with atrial fibrillation

Giuseppe Lippi et al.

WORLD JOURNAL OF CARDIOLOGY (2019)

Article Medicine, General & Internal

Volume, conductivity, and scatter parameters of leukocytes as early markers of sepsis and treatment response

Parul Arora et al.

JOURNAL OF LABORATORY PHYSICIANS (2019)

Article Critical Care Medicine

Cytomorphometric Neutrophil and Monocyte Markers May Strengthen the Diagnosis of Sepsis

Joy Mammen et al.

JOURNAL OF INTENSIVE CARE MEDICINE (2018)

Article Pathology

Role of leucocytes cell population data in the early detection of sepsis

Eloisa Urrechaga et al.

JOURNAL OF CLINICAL PATHOLOGY (2018)

Review Cell Biology

Mechanisms of Hemolysis During Sepsis

Katharina Effenberger-Neidnicht et al.

INFLAMMATION (2018)

Review Pharmacology & Pharmacy

Procalcitonin Monitoring as a Guide for Antimicrobial Therapy: A Review of Current Literature

Elizabeth W. Covington et al.

PHARMACOTHERAPY (2018)

Review Hematology

Best practice in critical care: anaemia in acute and critical illness

A. B. Docherty et al.

TRANSFUSION MEDICINE (2018)

Review Immunology

The Evolving Erythrocyte: Red Blood Cells as Modulators of Innate Immunity

H. Luke Anderson et al.

JOURNAL OF IMMUNOLOGY (2018)

Article Medicine, General & Internal

Correlation between neutrophil-to-lymphocyte ratio and severity scores in septic patients upon hospital admission. A series of 50 patients

Dimitrios Velissaris et al.

ROMANIAN JOURNAL OF INTERNAL MEDICINE (2018)

Article Medicine, General & Internal

Neutrophil-to-lymphocyte ratio and mean platelet volume can be useful markers to predict sepsis in children

Adem Dursun et al.

PAKISTAN JOURNAL OF MEDICAL SCIENCES (2018)

Article Critical Care Medicine

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Andrew Rhodes et al.

INTENSIVE CARE MEDICINE (2017)

Review Biochemistry & Molecular Biology

The Effect of Sepsis on the Erythrocyte

Ryon M. Bateman et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Cardiac & Cardiovascular Systems

Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics

Supreeth P. Shashikumar et al.

JOURNAL OF ELECTROCARDIOLOGY (2017)

Editorial Material Medicine, General & Internal

Recognizing Sepsis as a Global Health Priority - A WHO Resolution

Konrad Reinhart et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Critical Care Medicine

Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?

Antoine Dewitte et al.

ANNALS OF INTENSIVE CARE (2017)

Article Hematology

No relationship between red blood cell distribution width and microcirculatory alterations in septic patients

Vito Fontana et al.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION (2017)

Article Respiratory System

Early Identification and Treatment of Pathogens in Sepsis Molecular Diagnostics and Antibiotic Choice

Stefan Riedel et al.

CLINICS IN CHEST MEDICINE (2016)

Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Hematology

Platelets in Critical Illness

Marcel Levi

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2016)

Article Medicine, Research & Experimental

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil-lymphocyte count ratio for sepsis

Hui-Bing Zhang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

Review Medical Laboratory Technology

Procalcitonin and community-acquired pneumonia (CAP) in children

Bivona Giulia et al.

CLINICA CHIMICA ACTA (2015)

Article Emergency Medicine

The predictive value of red cell distribution width levels on mortality in intensive care patients with community-acquired intra-abdominal sepsis

Hatice Kaya Ozdogan et al.

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY (2015)

Review Medical Laboratory Technology

Red blood cell distribution width: A simple parameter with multiple clinical applications

Gian Luca Salvagno et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2015)

Article Medicine, General & Internal

A Randomized Trial of Protocol-Based Care for Early Septic Shock

Donald M. Yealy et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Critical Care Medicine

PERSISTENT LYMPHOPENIA AFTER DIAGNOSIS OF SEPSIS PREDICTS MORTALITY

Anne M. Drewry et al.

SHOCK (2014)

Article Microbiology

ERYTHROCYTE AND BLOOD ANTIBACTERIAL DEFENSE

Hayk Minasyan

EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY (2014)

Article Infectious Diseases

Delta Neutrophil Index as a Prognostic Marker of Early Mortality in Gram Negative Bacteremia

Hye Won Kim et al.

INFECTION AND CHEMOTHERAPY (2014)

Article Emergency Medicine

Red cell distribution width is a prognostic factor in severe sepsis and septic shock

You Hwan Jo et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2013)

Article Cell Biology

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

Raymond J. g Langley et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Review Hematology

Physiological Changes in Hematological Parameters During Pregnancy

Surabhi Chandra et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2012)

Article Multidisciplinary Sciences

The Neutrophil-Lymphocyte Count Ratio in Patients with Community-Acquired Pneumonia

Cornelis P. C. de Jager et al.

PLOS ONE (2012)

Article Critical Care Medicine

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis

Jonathan S. Boomer et al.

CRITICAL CARE (2012)

Article Hematology

Screening of sepsis using leukocyte cell population data from the Coulter automatic blood cell analyzer DxH800

D-H. Park et al.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY (2011)

Article Medicine, General & Internal

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

Jonathan S. Boomer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Article Hematology

Nomenclature of monocytes and dendritic cells in blood

Loems Ziegler-Heitbrock et al.

BLOOD (2010)

Article Critical Care Medicine

EARLY ASSESSMENT OF LEUKOCYTE ALTERATIONS AT DIAGNOSIS OF SEPTIC SHOCK

Fabienne Venet et al.

SHOCK (2010)

Article Critical Care Medicine

Sepsis and Septic Shock: A History

Duane J. Funk et al.

CRITICAL CARE CLINICS (2009)

Review Pharmacology & Pharmacy

Apoptosis in sepsis: Mechanisms, clinical impact and potential therapeutic targets

Alfred Ayala et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Review Hematology

Platelets, neutrophils, and neutrophil extracellular traps (NETs) in sepsis

A. C. Ma et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)

Review Immunology

Harmful molecular mechanisms in sepsis

Daniel Rittirsch et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Critical Care Medicine

Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units

Khalid Abidi et al.

CRITICAL CARE (2008)

Review Cell Biology

Leukocyte apoptosis and its significance in sepsis and shock

DE Wesche et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2005)

Article Infectious Diseases

Role of apoptotic cell death in sepsis

RS Hotchkiss et al.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2003)

Article Medicine, General & Internal

Anemia and blood transfusion in critically ill patients

JL Vincent et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)