Digital Pathology Transformation in a Supraregional Germ Cell Tumour Network

Article Pathology

Role of digital pathology in diagnostic histopathology in the response to COVID-19: results from a survey of experience in a UK tertiary referral hospital

Lisa Browning et al.

Summary: The COVID-19 pandemic has put pressure on our diagnostic services, and the use of digital pathology is on the rise globally, playing a role in maintaining diagnostic practices.

JOURNAL OF CLINICAL PATHOLOGY (2021)

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Review Pathology

Digital pathology and artificial intelligence will be key to supporting clinical and academic cellular pathology through COVID-19 and future crises: the PathLAKE consortium perspective

Lisa Browning et al.

Summary: The measures to control COVID-19 outbreak will likely continue until a suitable vaccine or treatment is found, impacting clinical services and research, with pathologists working remotely and changes to protocols and studies. Digital pathology and artificial intelligence may play a key role in safeguarding clinical services and pathology-based research in the current and future climate.

JOURNAL OF CLINICAL PATHOLOGY (2021)

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Review Pathology

Diagnostic concordance and discordance in digital pathology: a systematic review and meta-analysis

Ayesha S. Azam et al.

Summary: Digital pathology (DP) has the potential to revolutionize histopathology practice by improving efficiency and diagnostic accuracy. However, limited evidence of reliability has been a barrier to wider adoption. This meta-analysis showed equivalent performance of DP compared to light microscopy for routine diagnosis, with specific areas of diagnostic discrepancy identified.

JOURNAL OF CLINICAL PATHOLOGY (2021)

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Review Multidisciplinary Sciences

Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network

Gonzague de Pinieux et al.

Summary: The nationwide registry of sarcoma in France reveals a higher incidence of sarcoma and TIM than previously reported, with tumors with very low incidence being less likely to participate in clinical trials. The study also highlights the importance of comprehensive histological review in understanding sarcoma incidence and clinical trial participation.

PLOS ONE (2021)

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Review Pathology

Recommendations for cellular and molecular pathology input into clinical trials: a systematic review and meta-aggregation

Shujing Jane Lim et al.

Summary: The systematic review aimed to synthesize recommendations specific to pathology practice in clinical trials for trial protocol design. Seven synthesized recommendation statements include multidisciplinary collaboration in trial design, selection of accredited laboratory for work, quality assurance of pathology-related parameters, transparent reporting, policies on informatics and biospecimen tracking, and informed consent for specimen collection and retention.

JOURNAL OF PATHOLOGY CLINICAL RESEARCH (2021)

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Article Medical Laboratory Technology

Digital Pathology Initiatives and Experience of a Large Academic Institution During the Coronavirus Disease 2019 (COVID-19) Pandemic

Giovanni M. Lujan et al.

Summary: The pandemic acted as a catalyst for pathologists to adopt a digital workflow into their daily practice, realizing the logistic and technical advantages of such tools.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

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Article Oncology

The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer

Abhisek Ghosh et al.

Summary: Testicular cancer is common in men aged 15-34, with lymphovascular invasion being an important prognostic factor. An artificial intelligence algorithm has been developed to identify suspicious areas of lymphovascular invasion in testicular tumours. This tool shows promise for aiding pathologists in detecting lymphovascular invasion, although further development is needed before clinical use.

CANCERS (2021)

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Article Medical Laboratory Technology