4.6 Article

Advantages and Applications of Total-Body PET Scanning

Journal

DIAGNOSTICS
Volume 12, Issue 2, Pages -

Publisher

MDPI
DOI: 10.3390/diagnostics12020426

Keywords

total-body PET; oncology; FDG; drug development; PET; CT; inflammatory disease

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Total-body PET scanning has been studied in various fields and has advantages such as high detection sensitivity and long scan range. It can provide faster image acquisition with less radioactivity, and has potential applications in disease diagnosis, treatment response, and prognosis, aiming to improve patient care.
Recent studies have focused on the development of total-body PET scanning in a variety of fields such as clinical oncology, cardiology, personalized medicine, drug development and toxicology, and inflammatory/infectious disease. Given its ultrahigh detection sensitivity, enhanced temporal resolution, and long scan range (1940 mm), total-body PET scanning can not only image faster than traditional techniques with less administered radioactivity but also perform total-body dynamic acquisition at a longer delayed time point. These unique characteristics create several opportunities to improve image quality and can provide a deeper understanding regarding disease detection, diagnosis, staging/restaging, response to treatment, and prognostication. By reviewing the advantages of total-body PET scanning and discussing the potential clinical applications for this innovative technology, we can address specific issues encountered in routine clinical practice and ultimately improve patient care.

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