Journal
ACS OMEGA
Volume 7, Issue 3, Pages 3073-3082Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c06465
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Funding
- Russian Science Foundation [19-73-30012]
- Russian Science Foundation [19-73-30012] Funding Source: Russian Science Foundation
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This study characterized new 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate using various techniques and tested their antitumor activity. The complexes exhibited high cytotoxic effects against M-HeLa and A-549 cell lines, comparable to doxorubicin, and were twice as active as tamoxifen against the MCF-7 cell line. The cytotoxic mechanism of the complexes may involve induction of apoptosis through the mitochondrial pathway.
New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revealed against the M-HeLa and A-549 cell lines. Both complexes were 2 times more active toward the MCF-7 cell line than the breast cancer drug tamoxifen. The cytotoxic mechanism of complexes is assumed to be related to the induction of apoptosis through the mitochondrial pathway.
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