H2S/Thiols, NO•, and NO-/HNO: Interactions with Iron Porphyrins

In the past decade, gasotransmitters NO center dot and H2S have been thoroughly studied in biological contexts, as their biosynthesis and physiological effects became known. Moreover, an additional intricate crosstalk reaction scheme between these compounds and related species is thought to exist as part of the cascade signaling processes in physiological conditions. In this context, heme enzymes, as modeled by iron porphyrins, play a central role in catalyzing the key interconversions involved. In this work, iron porphyrin interactions with sulfide and nitric-oxide-related species are described. The stability and reactivity of mixed ternary systems are also described, and future perspectives are discussed.

Automated summary

In the past decade, gasotransmitters NO· and H2S have been extensively studied in biological contexts, uncovering their biosynthesis and physiological effects. There is believed to exist a complex crosstalk between these compounds and related species in physiological conditions. Iron porphyrins as heme enzymes play a central role in catalyzing key interconversions, with interactions with sulfide and nitric-oxide-related species being described in this work. The stability and reactivity of mixed ternary systems are also discussed along with future perspectives.