Journal
ACS OMEGA
Volume 6, Issue 40, Pages 25940-25949Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1c02645
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Funding
- National Natural Science Foundation of China [31672457]
- Hunan Province Science Foundation for Youths [2018JJ3215]
- Research Foundation of Education Bureau of Hunan Province [18C0147]
- Hunan Agricultural University Science Foundation for High-Level Personnel [17QN21]
- Double First-Class Construction Project of the Hunan Agricultural University [SYL2019064, SYL2019063, SYL201802003, YB2018007, CX20190497]
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The novel method described in this study achieves regioselective iodination of imidazo[1,2-alpha]pyridines at their C3 position without the need for metal catalysts, using ultrasound acceleration and a green alcohol solvent. This approach significantly improves reaction efficiency and rate compared to conventional heating systems, maximizing the iodine atom economy.
A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-alpha]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques.
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