Journal
ACS OMEGA
Volume 7, Issue 6, Pages 5274-5282Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.1C06443
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Funding
- Guangdong Basic and Applied Basic Research Foundation [2021A1515010012]
- Guangzhou Scientific Planning Program [202102020805]
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In this study, a copper-mediated decarboxylative coupling reaction of 3-indoleacetic acids with pyrazolones was described. This protocol allows for new functionalization of pyrazolones under simple reaction conditions and demonstrates high compatibility with different functional groups and wide substrate scope. Importantly, the resulting products exhibit antiproliferative activity against cancer cells.
A copper-mediated decarboxylative coupling reaction of 3-indoleacetic acids with pyrazolones was described. This protocol realized new functionalization of pyrazolones under simple reaction conditions and exhibited high functional group compatibility and broad substrate scope. Notably, the products displayed antiproliferative activity against cancer cells.
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