4.4 Article

Core-shell magnetic nanoparticles deliver singlet oxygen for mild oxidations: rechargeable, removable, reusable

Journal

MOLECULAR SYSTEMS DESIGN & ENGINEERING
Volume 7, Issue 4, Pages 325-329

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1me00186h

Keywords

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Funding

  1. LiaoNing Revitalization Talents Program [XLYC1902001]
  2. TUBITAK

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In this study, a novel approach for generating singlet oxygen on nanoparticles was presented. The modified nanoparticles can serve as a source of singlet oxygen through photosensitization or by thermal cycloreversion reaction. The nanoparticle-based agent can be easily recovered and reused, allowing for the availability of singlet oxygen in a convenient manner and broadening its scope of reactions.
Singlet oxygen is a useful reactive species. In addition to its role in photodynamic therapy, a variety of synthetically useful reactions can be carried out using singlet oxygen generated by photosensitization. In this work, we present a novel approach for synthetic applications, where singlet oxygen can be generated both via photosensitization and by thermal cycloreversion reaction of a singlet oxygen storage/photo-sensitizer compound on nanoparticles. With this goal in mind, a BODIPY photosensitizer-pyridone conjugate was covalently tethered to silica-iron oxide core-shell nanoparticles. The modified nanoparticles serve as singlet oxygen sources through photosensitization of the BODIPY core, or alternatively, once the pyridone module is transformed into an endoperoxide, they can be used as a chemical source of singlet oxygen under mild conditions in the dark. The nanoparticle-based agent can easily be recovered with a magnet and can be reused repeatedly. We expect ready and convenient availability of singlet oxygen to broaden the scope of reactions for this reactive oxygen species.

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