Journal
BRAIN SCIENCES
Volume 11, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/brainsci11121615
Keywords
cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); stroke; hypercoagulability; COVID-19; SARS-CoV-2; endothelial dysfunction
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COVID-19 infection and diseases such as CADASIL can both lead to endothelial dysfunction, increasing the risk of ischemic stroke. This study presents a case of a CADASIL patient developing an acute ischemic stroke after SARS-CoV-2 infection.
Background: SARS-CoV-2 infection has been associated with different neurological conditions such as Guillain-Barre, encephalitis and stroke. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small-vessel disease characterized by recurrent ischemic stroke, cognitive decline, migraine and mood disturbances. One of the mechanisms involved in CADASIL pathogenesis is endothelial dysfunction, which causes an increased risk of recurrent strokes. Since COVID-19 infection is also associated with coagulopathy and endothelial dysfunction, the risk of ischemic stroke might be even higher in this population. We describe the case of a CADASIL patient who developed an acute ischemic stroke after SARS-CoV-2 infection. In patients with diseases causing endothelial dysregulation, such as CADASIL, the hypercoagulability related to COVID-19 may contribute to the risk of stroke recurrence.
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