Journal
BRAIN SCIENCES
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/brainsci11111444
Keywords
multiple sclerosis; biomarker; intrathecal IgM synthesis; oligoclonal bands
Categories
Ask authors/readers for more resources
The presence of intrathecal IgM synthesis (ITMS) is associated with an aggressive clinical course of multiple sclerosis (MS), being higher in relapsing-remitting (RR) patients. The risk of second relapse is higher in OCGBs positive patients, but much higher in ITMS positive patients. This study suggests that the risk of a second relapse may be related to the presence of intrathecal IgM to some extent.
The presence of intrathecal IgM synthesis (ITMS) has been associated with an aggressive multiple sclerosis (MS) clinical course. In the present systematic review, we aimed at assessing the prevalence of ITMS among different MS phenotypes. Moreover, we aimed at quantifying the risk of a second relapse in ITMS positive and oligoclonal IgG bands (OCGBs)-positive patients. We selected clinical studies reporting the ITMS prevalence assessed as oligoclonal IgM Bands (OCMBs), lipid-specific OCMBs (LS-OCMBs), and/or as an intrathecal IgM production > 0% (IgMLoc, Reiber formula). The overall prevalence of ITMS was higher in relapsing-remitting (RR) than clinically isolated syndrome (CIS) patients (40.1% versus 23.8%, p < 0.00001), while was in line with that detected in primary progressive MS (PPMS, 26.7%). Almost all patients (98%) with ITMS had also OCGBs. The risk of having a second relapse was higher in OCGBs positive patients (HR = 2.18, p = 0.007) but much higher in ITMS positive patients (HR = 3.62, p = 0.0005). This study revealed that the prevalence of ITMS is higher in RRMS patients. It suggests that the risk of having a second relapse, previously ascribed to OCGBs, may, to a certain extent, be related to the presence of intrathecal IgM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available