Journal
ANTIBIOTICS-BASEL
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics11010109
Keywords
volatile organic compounds; volatiles; chemical ecology; metabolomics; antibacterial; antifungal; antibiotics; antimicrobial resistance crisis
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We are currently facing a crisis of antimicrobial resistance, and novel solutions are urgently needed. Bacterial volatiles, which are chemically diverse and exhibit antimicrobial activities, could be a new source of antimicrobial compounds. This review introduces the chemical diversity of bacterial volatiles, their antimicrobial activities, and testing methods, and discusses the potential use of antimicrobial volatiles to combat antimicrobial resistance crisis.
We are currently facing an antimicrobial resistance crisis, which means that a lot of bacterial pathogens have developed resistance to common antibiotics. Hence, novel and innovative solutions are urgently needed to combat resistant human pathogens. A new source of antimicrobial compounds could be bacterial volatiles. Volatiles are ubiquitous produced, chemically divers and playing essential roles in intra- and interspecies interactions like communication and antimicrobial defense. In the last years, an increasing number of studies showed bioactivities of bacterial volatiles, including antibacterial, antifungal and anti-oomycete activities, indicating bacterial volatiles as an exciting source for novel antimicrobial compounds. In this review we introduce the chemical diversity of bacterial volatiles, their antimicrobial activities and methods for testing this activity. Concluding, we discuss the possibility of using antimicrobial volatiles to antagonize the antimicrobial resistance crisis.
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