4.6 Article

Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents

Journal

ANTIBIOTICS-BASEL
Volume 10, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/antibiotics10111413

Keywords

A. nemorosa & nbsp; ; Trypanosoma brucei; farnesene; nanoemulsions; artificial mixtures

Funding

  1. University of Camerino
  2. Italian Ministry of Health
  3. Swedish Research Council [2019-01242]
  4. [FAR 2018]
  5. Swedish Research Council [2019-01242] Funding Source: Swedish Research Council

Ask authors/readers for more resources

This study investigated the susceptibility of Trypanosoma brucei to Anthriscus nemorosa essential oils and their isolated compounds, shedding light on their potential as antiparasitic agents. The research also revealed a disrupted energy metabolism in trypanosomes exposed to the essential oils, indicating the efficacy of Anthriscus nemorosa EO in developing effective antiparasitic formulations, including nanoemulsions.
This study aimed to investigate the susceptibility of Trypanosoma brucei to the Anthriscus nemorosa essential oils (EOs), isolated compounds from these oils, and artificial mixtures of the isolated compounds in their conventional and nanoencapsulated forms. The chemical composition of the essential oils from the aerial parts and roots of Anthriscus nemorosa, obtained from a wild population growing in central Italy, were analyzed by gas chromatography/mass spectrometry (GC/MS). In both cases, the predominant class of compounds was monoterpene hydrocarbons, which were more abundant in the EOs from the roots (81.5%) than the aerial parts (74.0%). The overall results of this work have shed light on the biological properties of A. nemorosa EO from aerial parts (EC50 = 1.17 mu g/mL), farnesene (EC50 = 0.84 mu g/mL), and artificial mixtures (Mix 3-5, EC50 in the range of 1.27 to 1.58 mu g/mL) as relevant sources of antiprotozoal substances. Furthermore, the pool measurements of ADP (adenosine diphosphate) and NTPs (nucleoside triphosphates) in the cultivated bloodstream form of trypanosomes exposed to different concentrations of EOs showed a disturbed energy metabolism, as indicated by increased pools of ADP in comparison to ATP (adenosine triphosphate) and other NTPs. Ultimately, this study highlights the significant efficacy of A. nemorosa EO to develop long-lasting and effective antiprotozoal formulations, including nanoemulsions.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available