Journal
ANTIBIOTICS-BASEL
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics10111343
Keywords
silver; nanoparticles; Punica granatum; wound healing; Staphylococcus aureus; Candida albicans
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Funding
- Sao Paulo Research Foundation (FAPESP), Brazil [2016/04230-9]
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The study found that both silver nanoparticles showed significant improvement in wound healing within the first 7 days of treatment. After 14 days, all treatments were superior to controls and significantly reduced the amount of S. aureus. CS exhibited better anti-inflammatory results, while GS and CS had the highest number of fibroblasts.
Infected cutaneous ulcers from diabetic rats with Candida albicans and Streptococcus aureus were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant S. aureus reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques' limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included.
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