Clinical management of hronic kidney disease-associated pruritus: current treatment options and future approaches

Chronic kidney disease (CKD)-associated pruritus (CKD-aP) is an underdiagnosed yet severely distressing condition that impacts 60% of patients on dialysis and many nondialysis patients with Stages 3-5 CKD. However, despite its high prevalence, there are currently limited treatment options available for these patients and a lack of treatment guidelines for clinicians. In this manuscript, we reviewed the available literature in order to evaluate the current management and treatment options for CKD-aP, including dialysis management, topical treatments, gabapentinoids, opioids and alternative medicine. We also review the available data on CKD-aP treatments in development and propose new guidelines for managing patients with CKD-aP.

Automated summary

CKD-aP is a highly prevalent and distressing condition impacting dialysis and nondialysis patients, yet there are limited treatment options and guidelines available. This review evaluated current management and treatment options, including emerging therapies, and proposed new guidelines for managing patients with CKD-aP.