Journal
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Volume 26, Issue 9, Pages 1564-1570Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/IGC.0000000000000828
Keywords
lncRNA; Ovarian cancer; HOTAIR; H19; XIST; HOST2
Categories
Funding
- Natural Science Foundation of China [81572577, 81372366, 81672993]
- Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund of National Natural Science Foundation of China [81428018]
- 111 project [111-2-12]
- Hunan Province Natural Science Foundation of China [2016JJ1027, 2016JC2035]
- Project of Innovation-driven Plan of Central South University [2016CX023]
- Open-End Fund for the Valuable and Precision Instruments of Central South University
- Fundamental Research Funds for the Central Universities of Central South University
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Ovarian cancer is the leading cause of death among women with gynecologic malignancies. The development and progression of ovarian cancer are complex and a multiple-step process. New biomarker molecules for diagnostic and prognostic are essential for novel therapeutic targets and to extend the survival time of patients with ovarian cancer. Long noncoding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides that have recently been found as key regulators of various biological processes and to be involved in the development and progression of many diseases including cancers. In this review, we summarized the expression pattern of several dysregulated lncRNAs (HOTAIR, H19, XIST, and HOST2) and the functional molecular mechanism of these lncRNAs on the initiation and progression of ovarian cancer. The lncRNAs as biomarkers may be used for current and future clinical diagnosis, therapeutics, and prognosis.
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