Journal
FOODS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/foods10112629
Keywords
Zein; 7,8-dihydroxyflavone; sophorolipid; polysaccharide; ternary nanoparticles
Categories
Funding
- Zhejiang Province PublicWelfare Technology Application Research Project-National Cooperation Project [LGJ21C20001]
- Fund of Key Laboratory of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs, China [NYJG202104]
- Zhejiang Province Xinmiao Talents Program [2021R403035]
- College students' Innovation and Entrepreneurship Training program of China [2021052, 2021011]
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This study found that the type of polysaccharide significantly affected the performance of nanoparticles, with CMC/S/Z showing better stability and ALG/S/Z exhibiting higher bioaccessibility.
In this study, two polysaccharides [sodium alginate (ALG) and sodium carboxymethyl cellulose (CMC)] were selected to establish zein/sophorolipid/ALG (ALG/S/Z) and zein/sophorolipid/ALG (CMC/S/Z) nanoparticles to encapsulate 7,8-dihydroxyflavone (7,8-DHF), respectively. The results showed that polysaccharide types significantly affected performance of ternary nanoparticles, including CMC/S/Z possessed lower polydispersity index, particle size and turbidity, but higher zeta potential, encapsulation efficiency and loading capacity compared to ALG/S/Z. Compared to zein/sophorolipid nanoparticles (S/Z), both ALG/S/Z and CMC/S/Z had better stability against low pH (pH 3 similar to 4) and high ionic strengths (150 similar to 200 mM NaCl). Hydrophobic effects, electrostatic interactions and hydrogen bonding were confirmed in ternary nanoparticles fabrication via Fourier-transform infrared spectroscopy. Circular dichroism revealed that CMC and ALG had no evident impact on secondary structure of zein in S/Z, but changed surface morphology of S/Z as observed by scanning electron microscope. Encapsulated 7,8-DHF exhibited an amorphous state in ternary nanoparticles as detected by X-ray diffraction and differential scanning calorimetry. Furthermore, compared to S/Z, ALG/S/Z, and CMC/S/Z remarkably improved the storage stability and bioaccessibility of 7,8-DHF. CMC/S/Z possessed a greater storage stability for 7,8-DHF, however, ALG/S/Z exhibited a better in vitro bioaccessibility of 7,8-DHF. This research provides a theoretical reference for zein-based delivery system application.
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