Journal
FOODS
Volume 10, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/foods10112804
Keywords
bee pollen; phenolic characterization; biological potential; functional food; antioxidant effects
Categories
Funding
- FEDER funds through the POCI-COMPETE 2020-Operational Programme Competitiveness and Internationalisation in Axis IStrengthening research, technological development and innovation [POCI-01-0145-FEDER-007491]
- Operational Program of the Center [CENTRO-01-0247-FEDER-017547]
- FCT-Foundation for Science and Technology [UID/Multi/00709/2013]
- R&D Business Project [CENTRO-01-0247-FEDER-017547]
- European Regional Development Fund (ERDF) through the Regional Operational Program of the Center (Portugal 2020)
- Foundation for Science and Technology (FCT)
- Ministry of Science, Technology and Higher Education (MCTES)
- European Social Fund (EFS)
- Europe Union (EU) [2020.04947.BD]
- Grant for Research Group of ExcellenceFundacion Seneca, Murcia Regional Agency for Science and Technology at CEBAS-CSIC [19900/GERM/15]
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The study found that bee pollen from Abrantes, Portugal, contains a variety of phenolic compounds, showing significant antioxidant and anti-diabetic properties, as well as the ability to protect human erythrocytes against oxidative damage. The pollen also did not exhibit cytotoxic effects in various cell lines, suggesting potential health-promoting effects for developing pharmaceutical drugs, nutraceuticals, and dietary supplements.
The aim of this study was to determine the grain composition and (poly)phenolic profile of pollen from Abrantes (Portugal), as well as its antioxidative and antidiabetic properties, and abilities to protect human erythrocytes against induced hemoglobin oxidation, lipid peroxidation, and hemolysis. The phytochemical profile of the Abrantes' bee pollen revealed twenty phenolic compounds, identified by high-performance liquid chromatography with electrospray ionization mass spectrometry coupled with photodiode array detection. Among them, quercetin derivatives were the most abundant. Concerning the biological potential, the pollen extract showed notable capacity for 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, and superoxide radicals, as well as for inhibition of alpha-glucosidase action, and protection of human erythrocytes against oxidative damage. Non-cytotoxic effects regarding the NHDF normal cell line, human adenocarcinoma Caco-2, and human liver HepG2 cells were observed. The results obtained contributed to further research on modes of action related to oxidative damage and metabolic health problems, to generate deeper knowledge of potential health-promoting effects to develop novel pharmaceutical drugs, nutraceuticals, and dietary supplements.
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