Journal
FOODS
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/foods11020151
Keywords
2 '-fucosyllactose; aging; SIRT1; gut microbiota
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Funding
- Fundamental Research Funds for the Central Universities, Nan-kai University [63211130, 63211142]
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The study found that 2'-FL has protective effects on the intestines and brain of aging mice, reducing oxidative stress damage and inflammation. In addition, it improves gut barrier function, increases short-chain fatty acid content in the intestine, and increases the abundance of probiotics. In the brain, 2'-FL significantly inhibits apoptosis and increases the expression of SIRT1.
The imbalance of reactive oxygen species is the main cause in aging, accompanied by oxidative stress. As the most abundant in human milk oligosaccharides (HMOs), 2 & PRIME;-Fucosyllactose (2 & PRIME;-FL) has been confirmed to have great properties in immunity regulation and anti-inflammatory. The research on 2 & PRIME;-FL is focused on infants currently, while there is no related report of 2 & PRIME;-FL for the elderly. A d-galactose-induced accelerated aging model was established to explore the protective effect of 2 & PRIME;-FL on the intestines and brain in mice. In this study, 2 & PRIME;-FL significantly reduced oxidative stress damage and inflammation in the intestines of aging mice, potentially by regulating the sirtuin1 (SIRT1)-related and nuclear factor E2-related factor 2 (Nrf2) pathways. In addition, 2 & PRIME;-FL significantly improved the gut mucosal barrier function and increased the content of short-chain fatty acids (SCFAs) in the intestine. The gut microbiota analysis indicated that 2 & PRIME;-FL mainly increased the abundance of probiotics like Akkermansia in aging mice. Moreover, 2 & PRIME;-FL significantly inhibited apoptosis in the brains of aging mice, also increasing the expression of SIRT1. These findings provided a basis for learning the benefits of 2 & PRIME;-FL in the aging process.
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