Journal
EUROPEAN THYROID JOURNAL
Volume 11, Issue 2, Pages -Publisher
BIOSCIENTIFICA LTD
DOI: 10.1530/ETJ-21-0016
Keywords
testicular metastases; medullary thyroid cancer; multiple endocrine neoplasia 2A syndrome
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This article reports the first known case of asymptomatic bilateral testicular metastases of medullary thyroid cancer (MTC). It highlights the importance of considering the testis as a potential metastatic site of MTC, especially in patients with advanced disease.
Introduction: Medullary thyroid cancer (MTC) is a rare endocrine tumor, which can be sporadic or familial, as a component of multiple endocrine neoplasia 2 (MEN2). Overall, 10% of MTC cases have already developed at presentation or will develop metastasis during follow-up. Testicular metastases are exceptional and only one case of unilateral testis involvement by metastatic MTC has been already reported in literature. We described the first known case of asymptomatic bilateral testicular MTC metastases, discovered incidentally at testicular ultrasound (US) performed for unrelated reasons. Case presentation: A Latin American 32-year-old man with MEN 2A syndrome and metastatic MTC underwent andrological and urological examination due to premature ejaculation. US imaging showed two symmetrical hypoechoic lesions involving both testes. Suspecting a bilateral testicular cancer, the patient underwent excision biopsy of both testicular lesions. Histopathology and immunohistochemical examinations documented metastatic MTC of both testicular lesions. Conclusion: Beyond its rarity, testis should be considered as a potential metastatic site of MTC, especially in patients with advanced disease.
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