Journal
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
Volume 26, Issue 4, Pages 785-789Publisher
BMJ PUBLISHING GROUP
DOI: 10.1097/IGC.0000000000000656
Keywords
Bartholin's gland carcinoma; Vulvar carcinoma; Bartholin's gland
Categories
Funding
- Raby/Dunaway Family Fund
- National Institutes of Health through MD Anderson's Cancer Center Support Grant [CA016672]
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Objective: Primary carcinoma of the Bartholin gland is a rare malignancy that accounts for approximately 5% of vulvar carcinomas. The aim of the study was to compare the outcomes of women with primary Bartholin gland carcinoma (BGC) with those with non-Bartholin gland related vulvar carcinoma. Materials and Methods: A retrospective chart review of 429 patients with invasive vulvar carcinoma evaluated at a single institution between 1993 and 2011 was performed. Medical records were reviewed for demographic data, pathologic information, treatment type, and recurrence/outcome information. These variables were compared between patients with primary BGC and patients with non-Bartholin gland related vulvar carcinoma. Results: Thirty-three (7.7%) of the 429 patients with invasive vulvar carcinoma had primary carcinoma of the Bartholin gland. Twenty-nine patients (87.9%) had squamous cell histology and 4 patients (12.1%) had adenocarcinoma. When compared with non-Bartholin gland related vulvar carcinoma, patients with primary BGC had a younger age at diagnosis (median, 57 vs 63 years; P = 0.045), had a higher rate of stage III/IV disease (60.6% vs 35.8%; P= 0.008), and were more likely to receive radiation therapy (78.8% vs 43.9%; P< 0.001). However, there were no significant differences between the 2 groups with regard to histologic subtype, lymphovascular space involvement, perineural invasion, positive margins, recurrence-free survival, or overall survival. Conclusions: Despite being diagnosed at a more advanced stage, patients with primary carcinoma of the Bartholin gland seem to have similar oncologic outcomes and survival rates to patients with non-Bartholin gland related vulvar carcinoma.
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