Journal
METABOLITES
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/metabo11110747
Keywords
cardiovascular health; lipidomics; sphingolipids; phospholipids; mass spectrometry
Categories
Funding
- National Program of Sustainability II (MEYS CR) [LQ1605]
- European Regional Development Fund-Project ENOCH [CZ.02.1.01/0.0/0.0/16_019/0000868]
- European Regional Development Fund-Project MAGNET [CZ.02.1.01/0.0/0.0/15_003/0000492]
- Mayo Clinic department of Cardiovascular Medicine
- FNUSA-ICRC [CZ.02.2.69/0.0/0.0/16_027/0008359]
- Marriot Heart Disease Research Program
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The study found that good cardiovascular health metrics are associated with a specific pattern of phospho- and sphingolipids. Circulatory lipid profiling may be a potential biomarker to refine cardiovascular health status in primary prevention strategies.
Ideal cardiovascular health (CVH) is defined for the presence of ideal behavioral and health metrics known to prevent cardiovascular disease (CVD). The association of circulatory phospho- and sphingo-lipids to primary reduction in cardiovascular risk is unclear. Our aim was to determine the association of CVH metrics with the circulating lipid profile of a population-based cohort. Serum sphingolipid and phospholipid species were extracted from 461 patients of the randomly selected prospective Kardiovize study based on Brno, Czech Republic. Lipids species were measured by a hyphenated mass spectrometry technique, and were associated with poor CVH scores, as defined by the American Heart Association. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE) species were significantly lower in ideal and intermediate scores of health dietary metric, blood pressure, total cholesterol and blood fasting glucose compared to poor scores. Current smokers presented higher levels of PC, PE and LPE individual species compared to non-smokers. Ceramide (Cer) d18:1/14:0 was altered in poor blood pressure, total cholesterol and fasting blood glucose metrics. Poor cardiovascular health metric is associated with a specific phospho- and sphingolipid pattern. Circulatory lipid profiling is a potential biomarker to refine cardiovascular health status in primary prevention strategies.
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