Journal
METABOLITES
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/metabo11110794
Keywords
cardioprotection; East Asians; diabetes mellitus; SGLT2 inhibitors; insulin independent
Categories
Funding
- Deanship of Scientific Research at Jouf University, Saudi Arabia [DSR-2021-01-0321]
Ask authors/readers for more resources
In East Asians, the incidence of type 2 diabetes has increased, with a higher risk of cardiovascular problems. SGLT2 inhibitors are novel insulin-independent antihyperglycemic drugs that not only improve glycemic control, but also have positive cardiovascular effects in East Asians.
In East Asians, the incidence of type 2 DM (T2DM) has increased as a result of major alterations in life. Cardiovascular problems are more likely in those with T2DM. Sodium-glucose cotransporter-2 (SGLT2) inhibitors are novel insulin-independent antihyperglycemic drugs that limit renal glucose reabsorption and thereby improve glycemic control. They are used alone or in combination with insulin and other antihyperglycemic medications to treat diabetes, and they are also helpful in protecting against the progression of complications. This review has evaluated the available evidence not only on the efficacy of SGLT2 inhibitors in T2DM, but also on their favourable cardiovascular events in East Asians. DM is an independent risk factor for cardiovascular diseases. As a result, in addition to glycemic control in diabetes management, the therapeutic goal in East Asian diabetic patients should be to improve adverse cardiovascular outcomes. Besides establishing antidiabetic effects, several studies have reported cardioprotective benefits of SGLT2 inhibitors via numerous pathways. SGLT2 inhibitors show promising antidiabetic drugs with potential cardiovascular advantages, given that a high number of diabetic patients in East Asia have co-existing cardiovascular disorders. Despite significant positive results in favour of SGLT2, more research is needed to determine how SGLT2 inhibitors exert these impressive cardiovascular effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available