Immune Function in Critically Ill Septic Children

The inflammatory response in pediatric sepsis is highly dynamic and includes both pro- and anti-inflammatory elements that involve the innate and adaptive immune systems. While the pro-inflammatory response is responsible for the initial clinical signs and symptoms of sepsis, a concurrent compensatory anti-inflammatory response often results in an occult, but highly clinically relevant, form of acquired immunodeficiency. When severe, this is termed immunoparalysis and is associated with increased risks for nosocomial infection, prolonged organ dysfunction, and death. This review focuses on the pathophysiology and clinical implications of both over- and under-active immune function in septic children. Host-, disease-, and treatment-specific risk factors for immunoparalysis are reviewed along with immune phenotype-specific approaches for immunomodulation in pediatric sepsis which are currently the subject of clinical trials.

Automated summary

The inflammatory response in pediatric sepsis is dynamic, involving both pro- and anti-inflammatory elements that can lead to acquired immunodeficiency. This review focuses on the pathophysiology and clinical implications of immune dysfunction in septic children, including risk factors for immunoparalysis and immunomodulation strategies currently under clinical trials.