Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.804396
Keywords
chronic liver diseases; liver fibrosis; nanotechnology; nanomedicine; targeted drug delivery
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Funding
- National Key R&D Program of China [2017YFA0205400]
- Jiangsu Outstanding Youth Funding [BK20190007]
- National Natural Science Foundation of China [8190032307]
- Medical Science and technology development Foundation, Nanjing Department of Health [JQX20005]
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Liver fibrosis is a reversible disease caused by various liver injuries, which can lead to severe complications. Traditional pharmacotherapy has limitations, while nanotechnology has shown great potential in liver fibrosis treatment.
Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment.
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