MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There's increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.

Automated summary

This article summarizes the important role of miRNA in breast tumor angiogenesis development, emphasizing the key roles of different miRNAs in disease processes, especially their overexpression in various diseases related to angiogenesis. More research is needed to reveal the relationship between miRNA expression and angiogenic pathways, immune response-related genes, and to provide more evidence for finding new therapeutic targets.