4.5 Article

CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Synaptic and complement markers in extracellular vesicles in multiple sclerosis

Pavan Bhargava et al.

Summary: This study found lower levels of NEV synaptic proteins and higher levels of multiple complement cascade components in AEVs in patients with multiple sclerosis compared to controls, suggesting that circulating EVs could serve as biomarkers for synaptic loss in MS and indicating a link between astrocytic complement production and synaptic loss.

MULTIPLE SCLEROSIS JOURNAL (2021)

Article Clinical Neurology

CSF extracellular vesicles and risk of disease activity after a first demyelinating event

Gloria Dalla Costa et al.

Summary: Extracellular vesicles (EVs) released from activated microglial cells and macrophages are a potential biomarker in diseases like multiple sclerosis. Research on cerebrospinal fluid EVs in patients with clinically isolated syndrome (CIS) found higher levels correlated with disease activity and may aid in risk stratification for targeted intervention strategies.

MULTIPLE SCLEROSIS JOURNAL (2021)

Review Clinical Neurology

A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy

A. Grayev et al.

Summary: The transforaminal approach is a safe alternative for intrathecal access in patients with spinal muscular atrophy and may be applicable to a larger patient population. Studies have found that this method has a low number of complications overall, indicating a high level of safety.

AMERICAN JOURNAL OF NEURORADIOLOGY (2021)

Article Biochemistry & Molecular Biology

MicroRNAs and Extracellular Vesicles as Distinctive Biomarkers of Precocious and Advanced Stages of Breast Cancer Brain Metastases Development

Ines Figueira et al.

Summary: The study on biomarkers of triple negative breast cancer brain metastases (BCBM) reveals miRNAs and EVs in the circulation as potential indicators of BCBM formation. Results suggest that circulating miRNAs and EVs of blood-brain barrier origin can be utilized as markers for early and advanced stages of BCBM detection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Clinical Neurology

Spinal Fluid Myeloid Microvesicles Predict Disease Course in Multiple Sclerosis

Stefano Gelibter et al.

Summary: CSF myeloid microvesicles serve as a promising biomarker for neuroinflammation and microglial/macrophage activity in multiple sclerosis, showing potential diagnostic and prognostic value in clinical practice.

ANNALS OF NEUROLOGY (2021)

Article Pharmacology & Pharmacy

Epsilon toxin from Clostridium perfringens induces toxic effects on skin tissues and HaCaT and human epidermal keratinocytes

Zhijun Geng et al.

Summary: This study evaluated the effects of ETX on HaCaT keratinocytes and human epidermal keratinocytes for the first time, revealing tissue edema and hemorrhage as consequences. The research also showed increased expression of aquaporin 3 in the muscle layer and skin follicles due to ETX, while confirming the presence of the MAL protein as a key element in the cytotoxic mechanism of ETX.

TOXICON (2021)

Article Cell Biology

Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin

Rosanne E. Veerman et al.

Summary: The method for isolating EVs impacts sample type, interest in EV subtypes, sample volume, and budget, and there is no one-size-fits-all method for all studies.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

Review Biochemistry & Molecular Biology

Lipid Rafts in Exosome Biogenesis

G. O. Skryabin et al.

BIOCHEMISTRY-MOSCOW (2020)

Article Cell Biology

Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure

Zhijun Geng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Editorial Material Clinical Neurology

Gadolinium should always be used to assess disease activity in MS - Yes

Cristina Granziera et al.

MULTIPLE SCLEROSIS JOURNAL (2020)

Article Multidisciplinary Sciences

Transcriptomic comparison of human and mouse brain microvessels

Hannah W. Song et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

Measuring Extracellular Vesicles by Conventional Flow Cytometry: Dream or Reality?

Donatella Lucchetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Emerging Role of Extracellular Vesicles in the Pathophysiology of Multiple Sclerosis

Ettore Dolcetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Veterinary Sciences

Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens

Jonatan Dorca-Arevalo et al.

VETERINARY RESEARCH (2020)

Review Biochemistry & Molecular Biology

Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases

Jing Tian et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Neurosciences

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

Rosa C. Paolicelli et al.

NEUROSCIENCE (2019)

Editorial Material Cell Biology

Extracellular vesicles: a new communication paradigm?

Graca Raposo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Cell Biology

Extracellular vesicles in type 2 diabetes mellitus: key roles in pathogenesis, complications, and therapy

Yongwei Xiao et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

Review Clinical Neurology

Role of Exosomes as a Treatment and Potential Biomarker for Stroke

Laura Otero-Ortega et al.

TRANSLATIONAL STROKE RESEARCH (2019)

Article Clinical Neurology

Quantifications of CSF Apoptotic Bodies Do Not Provide Clinical Value in Multiple Sclerosis

Ruturaj Masvekar et al.

FRONTIERS IN NEUROLOGY (2019)

Review Clinical Neurology

Multiple sclerosis - a review

R. Dobson et al.

EUROPEAN JOURNAL OF NEUROLOGY (2019)

Article Clinical Neurology

Multiple sclerosis: Serum-derived exosomes express myelin proteins

Grazyna Galazka et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Clinical Neurology

Multiple sclerosis: Serum-derived exosomes express myelin proteins

Grazyna Galazka et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

Article Critical Care Medicine

Exacerbation of Acute Traumatic Brain Injury by Circulating Extracellular Vesicles

Isla Hazelton et al.

JOURNAL OF NEUROTRAUMA (2018)

Article Hematology

Flow cytometric analysis of extracellular vesicle subsets in plasma: impact of swarm by particles of non-interest

S. F. W. M. Libregts et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Article Hematology

Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation

E. van der Pol et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Article Clinical Neurology

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J. Thompson et al.

LANCET NEUROLOGY (2018)

Article Biochemistry & Molecular Biology

The Cytotoxicity of Epsilon Toxin from Clostridium perfringens on Lymphocytes Is Mediated by MAL Protein Expression

Marta Blanch et al.

MOLECULAR AND CELLULAR BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Extracellular vesicles in obesity and diabetes mellitus

Fabian Pardo et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

Article Nanoscience & Nanotechnology

Absolute sizing and label-free identification of extracellular vesicles by flow cytometry

Edwin van der Pol et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis

Kimitoshi Kimura et al.

NATURE COMMUNICATIONS (2018)

Review Biotechnology & Applied Microbiology

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

Maria Yu. Konoshenko et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Article Biochemistry & Molecular Biology

The First Dose of Fingolimod Affects Circulating Extracellular Vesicles in Multiple Sclerosis Patients

Matias Saenz-Cuesta et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Clinical Neurology

New Insights Into Immune Cell-Derived Extracellular Vesicles in Multiple Sclerosis

Maria Blonda et al.

FRONTIERS IN NEUROLOGY (2018)

Review Biochemistry & Molecular Biology

Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding?

Helene Pollet et al.

BIOMOLECULES (2018)

Review Cell Biology

Exosome-Based Cell-Cell Communication in the Tumor Microenvironment

Joana Maia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Review Neurosciences

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Servio H. Ramirez et al.

FLUIDS AND BARRIERS OF THE CNS (2018)

Article Clinical Neurology

An updated histological classification system for multiple sclerosis lesions

Tanja Kuhlmann et al.

ACTA NEUROPATHOLOGICA (2017)

Article Multidisciplinary Sciences

Exosomal microRNA signatures in multiple sclerosis reflect disease status

Saeideh Ebrahimkhani et al.

SCIENTIFIC REPORTS (2017)

Review Cardiac & Cardiovascular Systems

Extracellular Vesicles in Cardiovascular Disease Potential Applications in Diagnosis, Prognosis, and Epidemiology

Felix Jansen et al.

CIRCULATION RESEARCH (2017)

Review Cardiac & Cardiovascular Systems

Extracellular Vesicles in Metabolic Syndrome

M. Carmen Martinez et al.

CIRCULATION RESEARCH (2017)

Article Clinical Neurology

Global Exosome Transcriptome Profiling Reveals Biomarkers for Multiple Sclerosis

Igor Selmaj et al.

ANNALS OF NEUROLOGY (2017)

Article Neurosciences

Sulfatides in Extracellular Vesicles Isolated From Plasma of Multiple Sclerosis Patients

Ana Lis Moyano et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2016)

Review Cell Biology

Biogenesis and Function of T Cell-Derived Exosomes

Leandro N. Ventimiglia et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

Article Immunology

Cutting Edge: Regulation of Exosome Secretion by the Integral MAL Protein in T Cells

Leandro N. Ventimiglia et al.

JOURNAL OF IMMUNOLOGY (2015)

Review Neurosciences

Exploring the origins of grey matter damage in multiple sclerosis

Massimiliano Calabrese et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Article Chemistry, Organic

Differential detergent sensitivity of extracellular vesicle subpopulations

Xabier Osteikoetxea et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Article Multidisciplinary Sciences

A survey of human brain transcriptome diversity at the single cell level

Spyros Darmanis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry

Heather Inglis et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

Article Cell Biology

Optimized exosome isolation protocol for cell culture supernatant and human plasma

Richard J. Lobb et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Review Immunology

Immunopathology of multiple sclerosis

Calliope A. Dendrou et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Clinical Neurology

Pathologic Heterogeneity Persists in Early Active Multiple Sclerosis Lesions

Imke Metz et al.

ANNALS OF NEUROLOGY (2014)

Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Review Medicine, Research & Experimental

Role of the Blood-Brain Barrier in Multiple Sclerosis

Genaro Gabriel Ortiz et al.

ARCHIVES OF MEDICAL RESEARCH (2014)

Article Medicine, Research & Experimental

Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis

Matias Saenz-Cuesta et al.

BIOMARKERS IN MEDICINE (2014)

Article Chemistry, Multidisciplinary

Refractive Index Determination of Nanoparticles in Suspension Using Nanoparticle Tracking Analysis

Edwin van der Pol et al.

NANO LETTERS (2014)

Article Neurosciences

Extracellular Vesicles in Multiple Sclerosis: What are They Telling Us?

Matías Sáenz-Cuesta et al.

Frontiers in Cellular Neuroscience (2014)

Article Biotechnology & Applied Microbiology

Extracellular vesicles: biology and emerging therapeutic opportunities

Samir EL Andaloussi et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Clinical Neurology

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

Claudia Verderio et al.

ANNALS OF NEUROLOGY (2012)

Article Hematology

Single vs. swarm detection of microparticles and exosomes by flow cytometry

E. Van der Pol et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2012)

Article Cell Biology

Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes

Olivier G. de Jong et al.

JOURNAL OF EXTRACELLULAR VESICLES (2012)

Review Clinical Neurology

The neuropathological basis of clinical progression in multiple sclerosis

Richard Reynolds et al.

ACTA NEUROPATHOLOGICA (2011)

Article Clinical Neurology

Evolution of the Blood-Brain Barrier in Newly Forming Multiple Sclerosis Lesions

Maria I. Gaitan et al.

ANNALS OF NEUROLOGY (2011)

Article Clinical Neurology

Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria

Chris H. Polman et al.

ANNALS OF NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

MAL, but not MAL2, expression promotes the formation of cholesterol-dependent membrane domains that recruit apical proteins

Sai P. Ramnarayanan et al.

BIOCHEMICAL JOURNAL (2011)

Article Immunology

The effects of high dose interferon-β1a on plasma microparticles: Correlation with MRI parameters

Mary Lowery-Nordberg et al.

JOURNAL OF NEUROINFLAMMATION (2011)

Review Hematology

Optical and non-optical methods for detection and characterization of microparticles and exosomes

E. van der Pol et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)

Article Biochemistry & Molecular Biology

The effects of blood-brain barrier disruption on glial cell function in multiple sclerosis

Stephen McQuaid et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2009)

Article Cell Biology

Clustering and Lateral Concentration of Raft Lipids by the MAL Protein

Lee Goldstein Magal et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Review Neurosciences

The Pathologic Substrate of Magnetic Resonance Alterations in Multiple Sclerosis

Hans Lassmann

NEUROIMAGING CLINICS OF NORTH AMERICA (2008)

Article Clinical Neurology

The immunopathology of multiple sclerosis:: An overview

Hans Lassmann et al.

BRAIN PATHOLOGY (2007)

Article Immunology

Interferon-β1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis

William A. Sheremata et al.

JOURNAL OF NEUROINFLAMMATION (2006)

Article Immunology

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide

Sulekha Verma et al.

BRAIN BEHAVIOR AND IMMUNITY (2006)

Article Biochemistry & Molecular Biology

Endothelial microparticles (EMP) bind and activate monocytes: Elevated empmonocyte conjugates in multiple sclerosis

W Jy et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2004)

Review Clinical Neurology

Blood-brain barrier disruption in multiple sclerosis

A Minagar et al.

MULTIPLE SCLEROSIS JOURNAL (2003)

Article Anatomy & Morphology

Characterization of GFP-MAL expression and incorporation in rafts

J Caduff et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2001)

Review Clinical Neurology

Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS

P van der Valk et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2000)