Journal
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
Volume 31, Issue 8, Pages 920-928Publisher
WILEY
DOI: 10.1002/gps.4409
Keywords
Alzheimer's disease (AD); amyloid-beta (A beta); positron emission tomography (PET); C-11-labeled Pittsburgh Compound B([C-11]PIB); depressive symptoms; precuneus/posterior cingulate cortex (PCu/PCC)
Categories
Funding
- Japan Society for the Promotion of Science [30346217, 15K09841]
- Health and Labour Sciences Research Grants, Research on Dementia from the Ministry of Health, Labour, and Welfare [H25-01]
- Grants-in-Aid for Scientific Research [15K09841] Funding Source: KAKEN
Ask authors/readers for more resources
Objective: Previous studies have reported depressive symptoms in the preclinical stages of Alzheimer's disease (AD). The objective of this study was to determine whether depressive symptoms are associated with cortical amyloid burden. In order to do this, we measured cortical amyloid via C-11-labeled Pittsburgh Compound B ([C-11]PIB) uptake using positron emission tomography (PET) in cognitively normal subjects. Methods: We performed [C-11]PIB-PET in 29 cognitively normal, older participants. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale (GDS). A beta deposition was quantified by binding potential (BPND), and the association between cortical mean BPND values and GDS scores was evaluated. Analysis of parametric BPND images was performed to examine the relationship between regional BPND and GDS scores. Results: We found a positive correlation between depressive symptoms and mean cortical PIB-BPND in groups of subjects with middle to high PIB-BPND. There was little change in GDS-depression score between subjects with low and middle PIB-BPND levels, while an increase in GDS was shown in the high PIB-BPND group. The main BPND increase was localized to the precuneus/posterior cingulate cortex (PCu/PCC) in subjects with high PIB-BPND, and we found a significant positive relationship between PIB-BPND in this area and depressive symptoms. Conclusions: Emotional dysregulation because of A beta neuropathology in the PCu/PCC may relate to depressive symptoms. More specifically, we found that older, cognitively normal patients with depressive episodes were more likely to have underlying AD pathology. Thus, depressive symptoms may increase the predictive ability of the identification of future AD cases. Copyright (C) 2016 John Wiley & Sons, Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available