Journal
MICROORGANISMS
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms9112225
Keywords
Streptomyces; secondary metabolites; biosynthetic potential; gene clusters; bioinformatics
Categories
Funding
- Spanish Ministry of Science, Innovation and Universities [MCIU-19-RTI2018-093562-B-I00, PRE2019-089448]
- University of Oviedo [PAPI-20-GR-2010-0019]
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By analyzing the genomes of 12 Streptomyces sp. strains isolated from leaf-cutting ants of the Attini tribe, it was revealed that over half of the predicted biosynthetic gene clusters were strain-specific, indicating the potential for novel compound discovery in this strain collection.
The rapid emergence of bacterial resistance to antibiotics has urged the need to find novel bioactive compounds against resistant microorganisms. For that purpose, different strategies are being followed, one of them being exploring secondary metabolite production in microorganisms from uncommon sources. In this work, we have analyzed the genome of 12 Streptomyces sp. strains of the CS collection isolated from the surface of leaf-cutting ants of the Attini tribe and compared them to four Streptomyces model species and Pseudonocardia sp. Ae150A_Ps1, which shares the ecological niche with those of the CS collection. We used a combination of phylogenetics, bioinformatics and dereplication analysis to study the biosynthetic potential of our strains. 51.5% of the biosynthetic gene clusters (BGCs) predicted by antiSMASH were unknown and over half of them were strain-specific, making this strain collection an interesting source of putative novel compounds.
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