4.6 Article

A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Janette Reader et al.

Summary: This study screened the Medicines for Malaria Venture Pandemic Response Box against different life cycle stages of Plasmodium, identifying unique compounds with multistage or stage-specific activity, including potent transmission-blocking drugs. Mechanistic investigations revealed that ML324 inhibits histone demethylation, leading to aberrant gene expression and death in gametocytes, while parasites resistant to SQ109 implicate the V-type H+-ATPase as a druggable target.

NATURE COMMUNICATIONS (2021)

Review Public, Environmental & Occupational Health

Tafenoquine and G6PD: a primer for clinicians

Cindy S. Chu et al.

JOURNAL OF TRAVEL MEDICINE (2019)

Review Microbiology

8-Aminoquinoline Therapy for Latent Malaria

J. Kevin Baird

CLINICAL MICROBIOLOGY REVIEWS (2019)

Article Multidisciplinary Sciences

Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target

Mahmood M. Alam et al.

SCIENCE (2019)

Article Infectious Diseases

Differential activity of methylene blue against erythrocytic and hepatic stages of Plasmodium

Henriette Bosson-Vanga et al.

MALARIA JOURNAL (2018)

Article Cell Biology

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Tanya Paquet et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Microbiology

Bioluminescence Method for In Vitro Screening of Plasmodium Transmission-Blocking Compounds

Raquel Azevedo et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

Article Pharmacology & Pharmacy

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats

Karen E. Parrish et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2016)

Article Medicine, General & Internal

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

Nicholas J. White et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Chemistry, Medicinal

Structure-Activity Relationship Studies of Orally Active Antimalarial 2,4-Diamino-thienopyrimidines

Diego Gonzalez Cabrera et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Beatriz Baragana et al.

NATURE (2015)

Article Immunology

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure

Sandie Menard et al.

EMERGING INFECTIOUS DISEASES (2015)

Article Chemistry, Medicinal

2,4-Diaminothienopyrimidines as Orally Active Antimalarial Agents

Diego Gonzalez Cabrera et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

Frederic Ariey et al.

NATURE (2014)

Article Microbiology

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

Benoit Witkowski et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Article Microbiology

Male and Female Plasmodium falciparum Mature Gametocytes Show Different Responses to Antimalarial Drugs

Michael J. Delves et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)

Article Cell Biology

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Aaron Nilsen et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Microbiology

Novel Potent Metallocenes against Liver Stage Malaria

Joana Matos et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Review Chemistry, Medicinal

Plasmodium kinases as targets for new-generation antimalarials

Isabelle S. Lucet et al.

FUTURE MEDICINAL CHEMISTRY (2012)

Article Computer Science, Interdisciplinary Applications

Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression

Herve Le Nagard et al.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2011)

Article Chemistry, Medicinal

Challenges in antimalarial drug discovery

Jeremy N. Burrows et al.

FUTURE MEDICINAL CHEMISTRY (2011)

Review Parasitology

A toolbox to study liver stage malaria

Miguel Prudencio et al.

TRENDS IN PARASITOLOGY (2011)

Article Microbiology

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

Benoit Witkowski et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)

Editorial Material Medicine, General & Internal

Artemisinin resistance-the clock is ticking

Nicholas J. White

LANCET (2010)

Article Multidisciplinary Sciences

Thousands of chemical starting points for antimalarial lead identification

Francisco-Javier Gamo et al.

NATURE (2010)

Article Multidisciplinary Sciences

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

Matthias Rottmann et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Improved synchronous production of Plasmodium falciparum gametocytes in vitro

Quinton L. Fivelman et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2007)

Article Microbiology

Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes

Francoise Benoit-Vical et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)

Article Microbiology

Simple and inexpensive fluorescence-based technique for high-throughput antimalarial drug screening

M Smilkstein et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)

Article Biochemistry & Molecular Biology

Hepatocyte CD81 is required for Plasmodium falciparum and Plasmodium yoelii sporozoite infectivity

O Silvie et al.

NATURE MEDICINE (2003)

Article Pharmacology & Pharmacy

Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys

SK Balani et al.

DRUG METABOLISM AND DISPOSITION (2002)