4.7 Article

Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling

Related references

Note: Only part of the references are listed.
Review Environmental Sciences

A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics

Jiachen Sun et al.

Summary: The exposure to environmental toxicants can lead to metabolic diseases, such as diabetes and obesity, through disturbances in key metabolic and signaling pathways. Research on metabolism disrupting chemicals (MDCs) becomes important to understand these risks. Various contaminants like EDCs, heavy metals, and emerging substances have been linked with metabolic disorders, highlighting the need for further studies on combined effects and metabolic alterations for better toxicity assessment and public health management.

ENVIRONMENT INTERNATIONAL (2022)

Review Biochemistry & Molecular Biology

The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review

Xingting Guo et al.

Summary: Enteroendocrine cells (EECs) originate from intestinal stem cells (ISCs) in both invertebrates and vertebrates, functioning in sensing environmental stimuli and regulating diverse biological processes. Advances in single-cell technology and genetic editing have led to a better understanding of EEC subtypes in mammals, while studies in genetic model organisms like Drosophila have provided insights into EEC specification processes. The comparison between mammalian and Drosophila EEC regulation highlights the importance of diverse subtypes and their impact on gastrointestinal physiology and pathophysiology.

FEBS JOURNAL (2022)

Article Cell Biology

An amuse-bouche of stem cell regulation: Underlying principles and mechanisms from adult Drosophila intestinal stem cells

Benjamin Boumard et al.

Summary: Stem cells play essential roles in organ development and maintenance, and understanding the mechanisms by which tissue-specific stem cells renew tissues is a key goal of regenerative medicine. The Drosophila midgut provides a widely used model system for studying regulatory mechanisms of stem cell biology.

CURRENT OPINION IN CELL BIOLOGY (2021)

Article Integrative & Complementary Medicine

Research Advances in Protective Effects of Ursolic Acid and Oleanolic Acid Against Gastrointestinal Diseases

Yajing Shi et al.

Summary: The intestinal tract plays a crucial role in protecting tissues from external harmful substances, but damage to the intestinal barrier can lead to systemic complications. Research indicates that ursolic acid and oleanolic acid can alleviate intestinal pathological injury and restore intestinal barrier function.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Review Cell Biology

The Role of Organelles in Intestinal Function, Physiology, and Disease

Siamak Redhai et al.

Summary: The intestine maintains homeostasis by coordinating internal biological processes to adjust to fluctuating external conditions. The intestinal epithelium comprises multiple cell types, including absorptive cells, secretory cells, and resident stem cells. An important feature of this organ is its ability to coordinate many processes using conserved signaling pathways, but the subcellular spatial organization of these events and the organelles involved has only recently been studied in detail.

TRENDS IN CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

DSS-induced colitis is associated with adipose tissue dysfunction and disrupted hepatic lipid metabolism leading to hepatosteatosis and dyslipidemia in mice

Jeonghyeon Kwon et al.

Summary: The study reveals a potential molecular mechanism linking colitis, hepatic steatosis, and dyslipidemia, suggesting disrupted metabolic processes as a key factor in the comorbidity of NAFLD and IBD.

SCIENTIFIC REPORTS (2021)

Article Biology

Defining cell types and lineage in the Drosophila midgut using single cell transcriptomics

Ruei-Jiun Hung et al.

Summary: The Drosophila midgut has become a model system for studying stem cell renewal, differentiation, and tissue homeostasis in recent years. Single cell transcriptomic methods have contributed significantly to our understanding of the diversity, lineage, and behavior of gut cell types.

CURRENT OPINION IN INSECT SCIENCE (2021)

Article Biochemistry & Molecular Biology

Reactive Oxygen Species in intestinal stem cell metabolism, fate and function

Otto Morris et al.

Summary: Reactive Oxygen Species (ROS) play critical signaling roles in the intestine, maintaining the regenerative capacity of Intestinal Stem Cells (ISCs). Declines in metabolic adaptations, through aging or pathology, result in reciprocal changes in ISC metabolism and ROS signaling, ultimately leading to aberrant ISC function and loss of tissue homeostasis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

Cyanidin-3-O-glucoside represses tumor growth and invasion in vivo by suppressing autophagy via inhibition of the JNK signaling pathways

Tian Wei et al.

Summary: BBSCE and its active component C3G demonstrated antitumor effects in a Drosophila model of malignant tumor by inhibiting both autonomous and non-autonomous autophagy pathways, leading to extended survival. The combination of C3G with the autophagy inhibitor chloroquine showed greater efficacy in inhibiting tumor growth, suggesting potential for cancer treatment and natural medicine development.

FOOD & FUNCTION (2021)

Article Biochemistry & Molecular Biology

Redox toxicology of environmental chemicals causing oxidative stress

Fuli Zheng et al.

REDOX BIOLOGY (2020)

Article Pharmacology & Pharmacy

Functional role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP) in lysosome localization and autophagy

Ryusuke Suzuki et al.

DRUG DISCOVERIES AND THERAPEUTICS (2020)

Article Developmental Biology

JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates

Salvador C. Herrera et al.

DEVELOPMENT (2019)

Article Genetics & Heredity

Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism

Dona R. Wisidagama et al.

G3-GENES GENOMES GENETICS (2019)

Article Multidisciplinary Sciences

Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

Parthive H. Patel et al.

NATURE COMMUNICATIONS (2019)

Article Pharmacology & Pharmacy

Ursolic Acid Improves Intestinal Damage and Bacterial Dysbiosis in Liver Fibrosis Mice

Si-Zhe Wan et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Dietary ursolic acid improves health span and life span in male Drosophila melanogaster

Stefanie Staats et al.

BIOFACTORS (2019)

Review Pharmacology & Pharmacy

Role of inulin as prebiotics on inflammatory bowel disease

Wasim Akram et al.

DRUG DISCOVERIES AND THERAPEUTICS (2019)

Article Genetics & Heredity

Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing

Jorge V. Beira et al.

PLOS GENETICS (2018)

Review Gastroenterology & Hepatology

The intestinal barrier: a fundamental role in health and disease

Maaike Vancamelbeke et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

What can flies tell us about zinc homeostasis?

Guiran Xiao et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Review Biochemistry & Molecular Biology

Intestinal stem cell response to injury: lessons from Drosophila

Huaqi Jiang et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Cell Biology

Drosophila tools and assays for the study of human diseases

Berrak Ugur et al.

DISEASE MODELS & MECHANISMS (2016)

Article Medicine, Research & Experimental

Identification of the protective effects of traditional medicinal plants against SDS-induced Drosophila gut damage

Yang Zhou et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

Article Multidisciplinary Sciences

Two phases of aging separated by the Smurf transition as a public path to death

E. Dambroise et al.

SCIENTIFIC REPORTS (2016)

Review Biochemistry & Molecular Biology

Clinical Relevance of Biomarkers of Oxidative Stress

Jeroen Frijhoff et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Article Biochemistry & Molecular Biology

Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut

Mate Naszai et al.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Pharmacology & Pharmacy

Enzymatic antioxidants and its role in oral diseases

J. Sathiya Jeeva et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2015)

Article Biochemistry & Molecular Biology

Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot

Mariano A. Loza-Coll et al.

EMBO JOURNAL (2014)

Article Biochemistry & Molecular Biology

Antibacterial and Antioxidant Activities of Ursolic Acid and Derivatives

Patricia G. G. do Nascimento et al.

MOLECULES (2014)

Review Immunology

Tissue communication in regenerative inflammatory signaling: lessons from the fly gut

Kristina Kux et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

Guiran Xiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Cell Biology

Drosophila melanogaster as a model for human intestinal infection and pathology

Yiorgos Apidianakis et al.

DISEASE MODELS & MECHANISMS (2011)

Article Gastroenterology & Hepatology

Epidemiology and Natural History of Inflammatory Bowel Diseases

Jacques Cosnes et al.

GASTROENTEROLOGY (2011)

Article Cell Biology

The role of JNK in the development of hepatocellular carcinoma

Madhumita Das et al.

GENES & DEVELOPMENT (2011)

Article Cell & Tissue Engineering

Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila

Alla Amcheslavsky et al.

CELL STEM CELL (2009)

Review Food Science & Technology

Ursolic acid: An anti- and pro-inflammatory, triterpenoid

Yasutaka Ikeda et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2008)

Article Chemistry, Medicinal

Ursolic acid: A potent inhibitor of superoxides produced in the cellular system

Muhammad S. Ali et al.

PHYTOTHERAPY RESEARCH (2007)

Review Biochemistry & Molecular Biology

JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species

HM Shen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Review Multidisciplinary Sciences

Self-renewal and cancer of the gut: Two sides of a coin

F Radtke et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster

LT Reiter et al.

GENOME RESEARCH (2001)