Journal
ANTIOXIDANTS
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/antiox11010091
Keywords
NAFLD; oxidative stress; ROS; mitochondria; ER stress; peroxisome; Kupffer cells; inflammation; hepatocytes; lipid metabolism; HSC; fibrosis; antioxidants
Funding
- National Research Foundation of Korea [2017R1A5A2015541, 2019R1A2C1090178]
- Ministry of Health and Welfare [HI20C0368]
- Korean Food and Drug Administration [20182MFDS425]
- Regional Innovation Strategy grant from the Ministry of Education, South Korea [2021RIS-001]
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This review summarizes the relationship between oxidative stress and the development of nonalcoholic fatty liver disease (NAFLD), and discusses the potential role of antioxidants as therapeutic agents for NAFLD.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and scientific studies consistently report that NAFLD development can be accelerated by oxidative stress. Oxidative stress can induce the progression of NAFLD to NASH by stimulating Kupffer cells, hepatic stellate cells, and hepatocytes. Therefore, studies are underway to identify the role of antioxidants in the treatment of NAFLD. In this review, we have summarized the origins of reactive oxygen species (ROS) in cells, the relationship between ROS and NAFLD, and have discussed the use of antioxidants as therapeutic agents for NAFLD.
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