Journal
ANTIOXIDANTS
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/antiox10121990
Keywords
plant secondary metabolites; antioxidant activity; drug discovery; multi-drug resistance (M; D; R; ); molecular docking; tuberculosis
Funding
- Dongguk University
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Tuberculosis is a progressive disease with high mortality rates, hindered by drug resistance of Mycobacterium tuberculosis. Plant-derived secondary metabolites are being explored for their potential in developing anti-TB drugs targeting the action site of the bacteria. Computational approaches can play a significant role in screening these plant metabolites against tuberculosis virulence for drug design.
Tuberculosis (TB) is a recurrent and progressive disease, with high mortality rates worldwide. The drug-resistance phenomenon of Mycobacterium tuberculosis is a major obstruction of allelopathy treatment. An adverse side effect of allelopathic treatment is that it causes serious health complications. The search for suitable alternatives of conventional regimens is needed, i.e., by considering medicinal plant secondary metabolites to explore anti-TB drugs, targeting the action site of M. tuberculosis. Nowadays, plant-derived secondary metabolites are widely known for their beneficial uses, i.e., as antioxidants, antimicrobial agents, and in the treatment of a wide range of chronic human diseases (e.g., tuberculosis), and are known to thwart disease virulence. In this regard, in silico studies can reveal the inhibitory potential of plant-derived secondary metabolites against Mycobacterium at the very early stage of infection. Computational approaches based on different algorithms could play a significant role in screening plant metabolites against disease virulence of tuberculosis for drug designing.
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