Journal
ANTIOXIDANTS
Volume 11, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/antiox11010111
Keywords
selenomethionine; neurotransmitter; D-galactose; oxidative stress; gut microbiota
Funding
- Agricultural Science and the Technology Innovation Program of Chinese Academy of Agricultural Sciences [CAAS-XTCX20190025-7]
- Leading Talent Project of Zhejiang Ten Thousand Talents Plan [2018R52025]
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This study found that selenomethionine (SeMet) has significant effects in improving age-related cognitive impairment. The results showed that SeMet improved the performance of mice with D-galactose-treated in various cognitive tests and reversed the biochemical abnormalities induced by D-galactose. Additionally, SeMet modulated the gut microbiota structure to alleviate dysbiosis caused by D-galactose. These findings provide evidence for the potential use of SeMet in preventing or adjuvant treatment of age-related cognitive impairment.
The prevalence of age-related cognitive impairment is increasing as the proportion of older individuals in the population grows. It is therefore necessary and urgent to find agents to prevent or ameliorate age-related cognitive impairment. Selenomethionine (SeMet) is a natural amino acid occurring in yeast and Brazil nuts. It mitigates cognitive impairment in an Alzheimer's disease mouse model, however, whether it works on age-related cognitive impairment remains unknown. In this study, SeMet significantly improved the performance of D-galactose-treated mice in the novel object recognition test, passive avoidance task and Morris water maze test. SeMet reversed D-galactose-induced reduction of hippocampal acetylcholine levels, suppression of choline acetyltransferase activity and activation of acetyl cholinesterase. It decreased D-galactose-induced oxidative stress and increased the selenoprotein P levels in the hippocampus. Besides, it attenuated D-galactose-induced dysbiosis by increasing the alpha-diversity and modulating the taxonomic structure. Correlations between certain taxa and physiological parameters were observed. Our results provide evidence of the effectiveness of SeMet on ameliorating D-galactose-induced cognitive impairment and suggest SeMet has potential to be used in the prevention or adjuvant treatment of age-related cognitive impairment.
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