Journal
BIOMOLECULES
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biom11111553
Keywords
sulfane sulfur; hydrogen sulfide; hydrogen persulfide; polysulfide; fluorescent probes
Categories
Funding
- JSPS KAKENHI [16H05099, 18H04609, 20H04767, 20H02701]
- SENTAN, JST
- Hoansha Foundation
- Daiichi Sankyo Foundation of Life Science
- Grants-in-Aid for Scientific Research [20H02701, 20H04767, 18H04609] Funding Source: KAKEN
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Hydrogen sulfide and its oxidation products play important roles in biological processes, with sulfane sulfur compounds attracting increasing interest for their physiological and pathophysiological roles. Traditional cyanolysis can be used to detect sulfane sulfur compounds, while recent studies have developed various chemical techniques for detection, isolation, and bioimaging of these compounds in biological samples.
Hydrogen sulfide and its oxidation products are involved in many biological processes, and sulfane sulfur compounds, which contain sulfur atoms bonded to other sulfur atom(s), as found in hydropersulfides (R-S-SH), polysulfides (R-S-S-n-S-R), hydrogen polysulfides (H2Sn), etc., have attracted increasing interest. To characterize their physiological and pathophysiological roles, selective detection techniques are required. Classically, sulfane sulfur compounds can be detected by cyanolysis, involving nucleophilic attack by cyanide ion to cleave the sulfur-sulfur bonds. The generated thiocyanate reacts with ferric ion, and the resulting ferric thiocyanate complex can be easily detected by absorption spectroscopy. Recent exploration of the properties of sulfane sulfur compounds as both nucleophiles and electrophiles has led to the development of various chemical techniques for detection, isolation, and bioimaging of sulfane sulfur compounds in biological samples. These include tag-switch techniques, LC-MS/MS, Raman spectroscopy, and fluorescent probes. Herein, we present an overview of the techniques available for specific detection of sulfane sulfur species in biological contexts.
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