The Synthesis and Biological Evaluation of D-Ring-Modified Vitamin D Analogues

The vitamin D-3 structure consists of the A-ring, a linker originating from the B-ring, C-ring, D-ring, and side-chain moieties. Each unit has its unique role in expressing the biological activities of vitamin D-3. Many efforts have been made to date to assess the possible clinical use of vitamin D. Some organic chemists focused on the D-ring structure of vitamin D and synthesized D-ring-modified vitamin D analogues, and their biological activities were studied. This review summarizes the synthetic methodologies of D-ring-modified vitamin D analogues, except for seco-D, and their preliminary biological profiles.

Automated summary

Different components of the structure of vitamin D-3 play unique roles in expressing its biological activities. Organic chemists have focused on D-ring-modified vitamin D analogues and studied their synthesis methods and biological properties.