Recombinant Proteins-Based Strategies in Bone Tissue Engineering

The increase in fracture rates and/or problems associated with missing bones due to accidents or various pathologies generates socio-health problems with a very high impact. Tissue engineering aims to offer some kind of strategy to promote the repair of damaged tissue or its restoration as close as possible to the original tissue. Among the alternatives proposed by this specialty, the development of scaffolds obtained from recombinant proteins is of special importance. Furthermore, science and technology have advanced to obtain recombinant chimera's proteins. This review aims to offer a synthetic description of the latest and most outstanding advances made with these types of scaffolds, particularly emphasizing the main recombinant proteins that can be used to construct scaffolds in their own right, i.e., not only to impregnate them, but also to make scaffolds from their complex structure, with the purpose of being considered in bone regenerative medicine in the near future.

Automated summary

The increase in fracture rates and missing bones poses significant socio-health problems. Tissue engineering, particularly the development of scaffolds from recombinant proteins, aims to promote tissue repair and restoration. This review provides a synthetic description of the latest advances in this field, highlighting the recombinant proteins that can be used to construct scaffolds for bone regenerative medicine.