Cytoplasmic and Nuclear Functions of cIAP1

Cellular inhibitor of apoptosis 1 (cIAP1) is a cell signaling regulator of the IAP family. Through its E3-ubiquitine ligase activity, it has the ability to activate intracellular signaling pathways, modify signal transduction pathways by changing protein-protein interaction networks, and stop signal transduction by promoting the degradation of critical components of signaling pathways. Thus, cIAP1 appears to be a potent determinant of the response of cells, enabling their rapid adaptation to changing environmental conditions or intra- or extracellular stresses. It is expressed in almost all tissues, found in the cytoplasm, membrane and/or nucleus of cells. cIAP1 regulates innate immunity by controlling signaling pathways mediated by tumor necrosis factor receptor superfamily (TNFRs), some cytokine receptors and pattern recognition-receptors (PRRs). Although less documented, cIAP1 has also been involved in the regulation of cell migration and in the control of transcriptional programs.

Automated summary

cIAP1 is a cell signaling regulator that can adapt cells to changing environmental conditions or stresses through modifying signal transduction pathways and promoting degradation of critical components of signaling pathways. It is widely expressed in cells and involved in regulating innate immunity and other cellular functions through controlling signaling pathways mediated by tumor necrosis factor receptor superfamily, cytokine receptors, and pattern recognition receptors.