Journal
BIOMOLECULES
Volume 11, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biom11111602
Keywords
human cancers; competing endogenous RNA; long noncoding RNA; KCNQ1OT1
Categories
Funding
- National Cancer Institute (NCI) [U01CA194730]
- National Institute on Minority Health and Health Disparities (NIMHD) [U54MD012392, R01MD012767]
Ask authors/readers for more resources
KCNQ1OT1 is an lncRNA involved in the development and progression of various cancers, regulating cancer cell functions and associated with poor prognosis in cancer patients.
Long noncoding RNAs (lncRNAs) are transcripts greater than 200 nucleotides that do not code for proteins but regulate gene expression. Recent studies indicate that lncRNAs are involved in the modulation of biological functions in human disease. KCNQ1 Opposite Strand/Antisense Transcript 1 (KCNQ1OT1) encodes a lncRNA from the opposite strand of KCNQ1 in the CDKN1C/KCNQ1OT1 cluster that is reported to play a vital role in the development and progression of cancer. KCNQ1OT1 regulates cancer cell proliferation, cell cycle, migration and invasion, metastasis, glucose metabolism, and immune evasion. The aberrant expression of KCNQ1OT1 in cancer patients is associated with poor prognosis and decreased survival. This review summarizes recent literature related to the biological functions and molecular mechanisms of KCNQ1OT1 in various human cancers, including colorectal, bladder, breast, oral, melanoma, osteosarcoma, lung, glioma, ovarian, liver, acute myeloid leukemia, prostate, and gastric. We also discuss the role of KCNQ1OT1 as a promising diagnostic biomarker and a novel therapeutic target in human cancers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available