A Review on Microbial Products and Their Perspective Application as Antimicrobial Agents

Microorganisms including actinomycetes, archaea, bacteria, fungi, yeast, and microalgae are an auspicious source of vital bioactive compounds. In this review, the existing research regarding antimicrobial molecules from microorganisms is summarized. The potential antimicrobial compounds from actinomycetes, particularly Streptomyces spp.; archaea; fungi including endophytic, filamentous, and marine-derived fungi, mushroom; and microalgae are briefly described. Furthermore, this review briefly summarizes bacteriocins, halocins, sulfolobicin, etc., that target multiple-drug resistant pathogens and considers next-generation antibiotics. This review highlights the possibility of using microorganisms as an antimicrobial resource for biotechnological, nutraceutical, and pharmaceutical applications. However, more investigations are required to isolate, separate, purify, and characterize these bioactive compounds and transfer these primary drugs into clinically approved antibiotics.

Automated summary

This review summarizes the research on antimicrobial molecules from microorganisms, briefly describing potential antimicrobial compounds from different types of microorganisms and highlighting the possibility of using microorganisms as a resource for antimicrobial applications. However, it also points out the need for further investigation to isolate, purify, and characterize these bioactive compounds in order to develop clinically approved antibiotics.