Journal
BIOMOLECULES
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biom11101524
Keywords
two-component signal transduction system; histidine kinase; autophosphorylation; phosphatase; ligand binding; PAS; intramembrane sensing; environmental signal sensing
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Funding
- JSPS KAKENHI [JP16K07681, JP19K07147, JP20K05796, JP20K15748]
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Two-component signal transduction systems are widely conserved in bacteria, serving as candidates for novel drug targets due to their involvement in controlling pathogen physiology. The diverse mechanisms of signal perception and response by HKs have been recently clarified, shedding light on their molecular mechanisms.
Two-component signal transduction systems (TCSs) are widely conserved in bacteria to respond to and adapt to the changing environment. Since TCSs are also involved in controlling the expression of virulence, biofilm formation, quorum sensing, and antimicrobial resistance in pathogens, they serve as candidates for novel drug targets. TCSs consist of a sensor histidine kinase (HK) and its cognate response regulator (RR). Upon perception of a signal, HKs autophosphorylate their conserved histidine residues, followed by phosphotransfer to their partner RRs. The phosphorylated RRs mostly function as transcriptional regulators and control the expression of genes necessary for stress response. HKs sense their specific signals not only in their extracytoplasmic sensor domain but also in their cytoplasmic and transmembrane domains. The signals are sensed either directly or indirectly via cofactors and accessory proteins. Accumulating evidence shows that a single HK can sense and respond to multiple signals in different domains. The underlying molecular mechanisms of how HK activity is controlled by these signals have been extensively studied both biochemically and structurally. In this article, we introduce the wide diversity of signal perception in different domains of HKs, together with their recently clarified structures and molecular mechanisms.
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