A Lateral Flow Immunoassay Coupled with a Spectrum-Based Reader for SARS-CoV-2 Neutralizing Antibody Detection

Article Medicine, General & Internal

Transmission event of SARS-CoV-2 delta variant reveals multiple vaccine breakthrough infections

Timothy Farinholt et al.

Summary: This study identified a cluster of 6 vaccinated patients infected with the delta variant, suggesting immune evasion in patients who received the Pfizer BNT162b2, Moderna mRNA-1273, and Covaxin BBV152 vaccines. The delta variant may pose the highest risk among currently circulating SARS-CoV-2 variants, with increased transmissibility over the alpha variant and potential vaccine breakthrough.

BMC MEDICINE (2021)

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Article Multidisciplinary Sciences

Neutralizing antibody titres in SARS-CoV-2 infections

Eric H. Y. Lau et al.

Summary: In this study, researchers quantified SARS-CoV-2 specific neutralizing antibodies using plaque reduction neutralization (PRNT) assays on 195 patients in different disease states. They found that patients with severe disease had higher peaks of neutralizing antibody titres than patients with mild or asymptomatic infections, and that serum neutralizing antibody persists for over 6 months in most people.

NATURE COMMUNICATIONS (2021)

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Article Biotechnology & Applied Microbiology

A Paper-Based IL-6 Test Strip Coupled With a Spectrum-Based Optical Reader for Differentiating Influenza Severity in Children

Sheng-Wen Lin et al.

Summary: Influenza virus infection is a major global health concern, particularly in children aged 5-14. The lack of effective early diagnosis tools leads to poor prognosis. The developed interleukin-6 paper-based test strip, when combined with a spectrum-based optical reader, offers a simple, rapid, and cost-effective method for diagnosing and monitoring severe influenza, showing high correlation with conventional assays and potential for accurate differentiation between mild and severe cases.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

David S. Khoury et al.

Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.

NATURE MEDICINE (2021)

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Article Chemistry, Analytical

Quantitative Spectrochip-Coupled Lateral Flow Immunoassay Demonstrates Clinical Potential for Overcoming Coronavirus Disease 2019 Pandemic Screening Challenges

Kai-Feng Hung et al.

Summary: As COVID-19 continues to spread, the use of lateral flow immunoassay devices and spectrochip technology enables quantitative analysis and high sensitivity in detecting anti-SARS-CoV-2 antibodies. The innovative device allows for early detection of infection and potential clinical benefits for patients.

MICROMACHINES (2021)

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Article Infectious Diseases

The durability of immunity against reinfection by SARS-CoV-2: a comparative evolutionary study

Jeffrey P. Townsend et al.

Summary: This study estimates the time to reinfection of SARS-CoV-2 using data from coronavirus relatives, finding that the protection period is shorter compared to other human-infecting coronaviruses. This information is crucial for public health decision-making.

LANCET MICROBE (2021)

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Article Immunology

Comparison of Antibody and T Cell Responses Induced by Single Doses of ChAdOx1 nCoV-19 and BNT162b2 Vaccines

Ji Yeun Kim et al.

Summary: Comparison of humoral and T cell responses after the first doses of ChAdOx1 nCoV-19 and BNT162b2 vaccines showed higher levels of antibodies in BNT162b2 recipients but similar T cell responses between the two groups.

IMMUNE NETWORK (2021)

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Article Immunology