Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Healthcare Workers before the Era of Vaccination at a Tertiary Care Hospital in Turkey

Editorial Material Anesthesiology

Occupational COVID-19 risk for anaesthesia and intensive care staff - low-risk specialties in a high-risk setting

T. M. Cook et al.

ANAESTHESIA (2021)

Review Public, Environmental & Occupational Health

Review Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis

P. Galanis et al.

Summary: The seroprevalence of SARS-CoV-2 antibodies among HCWs is relatively high and influenced by factors such as gender, race, work environment, and protective measures.

JOURNAL OF HOSPITAL INFECTION (2021)

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Article Medicine, General & Internal

Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel

Jesse T. Jacob et al.

Summary: The study found that healthcare personnel in three states in the USA were primarily influenced by community contact when it came to contracting the coronavirus, with workplace-related factors not showing a significant association. This indicates that current infection prevention practices in diverse healthcare settings are effective in preventing the transmission of SARS-CoV-2 from patients to healthcare personnel.

JAMA NETWORK OPEN (2021)

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Letter Infectious Diseases

Seroprevalence of antibodies against SARS-CoV-2 in a large national hospital and affiliated facility in Tokyo, Japan

Akihito Tanaka et al.

JOURNAL OF INFECTION (2021)

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Article Microbiology

SARS-CoV-2 Seroprevalence Among Healthcare Workers: Retrospective Analysis of the Data From A University Hospital in Turkey

Adem Ozdemir et al.

Summary: The seroprevalence of SARS-CoV-2 among healthcare workers in our hospital during the COVID-19 pandemic was found to be 7.4%, with a higher antibody positivity rate in individuals diagnosed with COVID-19. Nurses and residents had higher seropositivity rates compared to other occupational groups. Large-scale studies are needed for risk assessment in healthcare professionals.

MIKROBIYOLOJI BULTENI (2021)

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Article Public, Environmental & Occupational Health

Differences in risk for SARS-CoV-2 infection among healthcare workers

K. Miriam Elfstrom et al.

Summary: The research suggests that although healthcare workers, especially nurse assistants, who care for COVID-19 patients are at risk for SARS-CoV-2 infection, some units responsible for COVID-19 patients do not have an elevated risk. Significant variations in seroprevalences among similar units indicate that healthcare work-related risk of SARS-CoV-2 infection may be preventable.

PREVENTIVE MEDICINE REPORTS (2021)

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Review Infectious Diseases

The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis

Ilker Kayi et al.

Summary: The study found a SARS-CoV-2 seroprevalence rate of 8% among HCWs in 2020, before vaccinations started, with higher rates observed in male HCWs, HCWs from ethnic minorities, those with high exposure, and those exposed to the virus outside healthcare settings.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Microbiology

Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing Immunity

Benjamin T. Bradley et al.

Summary: The study investigated the performance characteristics of different SARS-CoV-2 antibody detection methods and examined the humoral response associated with vaccination, natural protection, and vaccine breakthrough infections.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Medicine, General & Internal

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey

Mine Durusu Tanriover et al.

Summary: The study presented the interim efficacy and safety results of the CoronaVac vaccine in a phase 3 clinical trial in Turkey, demonstrating high efficacy against PCR-confirmed symptomatic COVID-19 with good safety and tolerability profile. Results showed significant differences in the frequency of any adverse events between the vaccine and placebo groups, indicating excellent protective effects of the vaccine.

LANCET (2021)

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Review Medicine, General & Internal

Effectiveness of public health measures in reducing the incidence of covid-19, SARS-CoV-2 transmission, and covid-19 mortality: systematic review and meta-analysis

Stella Talic et al.

Summary: This systematic review and meta-analysis suggest that personal protective and social measures like handwashing, mask wearing, and physical distancing are associated with reductions in the incidence of COVID-19. However, due to heterogeneity of the studies, meta-analysis for other interventions like quarantine, isolation, universal lockdowns, and closures was not possible, and further research is needed.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Infectious Diseases

Risk Groups for SARS-CoV-2 Infection among Healthcare Workers: Community Versus Hospital Transmission

Fatihan Pinarlik et al.

Summary: A study conducted in 2020 before the vaccination era found that the infection rate among healthcare workers was 16.3%. Janitorial staff and medical secretaries were identified as high-risk groups for SARS-CoV-2 infection, along with healthcare workers with household members diagnosed with COVID-19.

INFECTIOUS DISEASE REPORTS (2021)

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Article Immunology

Coronavirus Disease 2019 (COVID-19) Seropositivity and Asymptomatic Rates in Healthcare Workers Are Associated with Job Function and Masking

Matthew D. Sims et al.

Summary: A study of 20,614 employees at Beaumont Health found that 8.8% tested positive for SARS-CoV-2 antibodies, with 44% of them being asymptomatic. Healthcare roles such as phlebotomy, respiratory therapy, and nursing/nursing support exhibited higher seropositivity. Participants who wore N95 masks when in contact with COVID-19 patients had a lower seropositivity rate compared to those wearing surgical/other masks or no mask.

CLINICAL INFECTIOUS DISEASES (2021)

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Review Infectious Diseases

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

Muge Cevik et al.

Summary: This study aimed to characterize the viral load dynamics, duration of viral shedding, and viable virus shedding of SARS-CoV-2 in various body fluids. The findings suggest that while SARS-CoV-2 RNA shedding can be prolonged in respiratory and stool samples, the duration of viable virus shedding is relatively short-lived.

LANCET MICROBE (2021)

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Review Medicine, General & Internal